Darunavir Dosing

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Get the Facts

Darunavir (Prezista)

What Is Darunavir? Darunavir is a drug used as part of antiretroviral therapy (ART). It is also called Prezista TM and used to be called TMC114. It is manufactured by Tibotec Pharmaceuticals. Darunavir is a protease inhibitor. These drugs prevent the protease enzyme from working. HIV protease acts like a chemical scissors. It cuts the raw material for HIV into specific pieces needed to build a new virus. Protease inhibitors "gum up" these...

Ask the Experts

Concerned with Darunavir dosage

Dear Docs, I am a hospital pharmacist who does a lot of HIV care and meds review and came across a patient with a dose of Darunavir that I can't make sense of. The pt is on Etravirine, Lamivudine, Raltegravir with correct dosing, and boosted...

Response from Joseph McGowan, M.D., F.A.C.P.

North Shore University Hospital

Dear Stephan,I wish there were more hospital pharmacists like you who really look into the doses and use of antiretrovirals. I agree I cannot think of any data to suypport the dose. The usual dose of darunavir here would be 600 mg twice daily.... Read more »

Darunavir Cross Resistance

35yo male, healthy, HIV positive (VL stable over the last years @ 25k, CD4 has always been between 720 and 780). My long-term partner is negative, and I finally decided to start treatment to decrease transmission risk. Phenotype and genotype test...

Response from Renslow Sherer, M.D.

University of Chicago Hospitals

A darunavir-based regimen with ritonavir boosting is among the preferred regimens in the current DHHS Guidelines for the Use of Antiretroviral Therapy, so the experts agree with you that this is a good option. Darunavir was added to the... Read more »

Darunavir or not to Darunavir + Low WBC

Hi Joe,I have another question for you. I have recently seen my consultant, and he has suggested changing PI's from Atazanavir to Darunavir. He quotes a few studies that suggest additional benefit for DRV. At the moment I'm undetectable on...

Response from Joseph McGowan, M.D., F.A.C.P.

North Shore University Hospital

Michael,Thanks for your questions. Darunavir is now approved for both first line treatment as well as for treatment experienced patients. It is a very potent protease inhibitor, but potency does not seem to be an issue with your regimen since you... Read more »

Darunavir, Ritonavir and Augmentin

I have been prescribed Augmentin for the treatment of bronchitis. Can this be taken with Darunavir and Ritonavir?...

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine

Generally OK to take darunavir/ritonavir with Augmentin. KH... Read more »

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Connect With Others

HALF DOSING MY MEDS

Posted by Anonymous, 1 Reply

Hello All !! I want to tell everyone that I started taking half of the prescribed doses of my meds about 2 years ago. My T cells remain High (570) and my V load is still undetectable..
I am on viramune,ziagen and zerit. I had an uncle who died... Read more »

dosing schedule adjustment

Posted by pozartistsd, 1 Reply

hey all you experts out there! I think i may know the answer to this but would like to get some input:

I currently take my meds (Reyataz/Truvada/Norvir) once a day. I take them at 9am (with breakfast, not that you need to know that

) I would like... Read more »

Skipping Doses

Posted by chrisnxs, 2 Replies

Hello Everyone, can someone please elaborate on the severity of skipping meds? My bf is positive and has been on meds for about a year. He's on my insurance and it kills the price down to a point where he can get his meds pretty easily. I discovered... Read more »

Low-Dose Naltrexone

Posted by renevatio, 1 Reply

Hello all-

I am newly diagnosed, and just getting into the process of researching all about HIV and potential alternative treatments. I am a voracious reader and spend a good bit of time each day reading papers and digging up info on my new internal... Read more »

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