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4th Generation Test Window Period

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Ask the Experts

4th generation ELISA test accuracy

Hi Dr Wohl,Thank you for the wonderful work you are doing!I am bit confused regarding the type of test to take and their respective window periods. It seems that the antibody test after 3 months has been the standard, but I have been reading that...
David Wohl, M.D.

Response from David Wohl, M.D.

University of North Carolina - Chapel Hill
The p24 component of this test turns positive in about t a week after infection. Therefore, at 5 weeks a negative test is very reliable. DW... Read more »

4th generation testing

It seems the only way anybody gets a for certain "your negative" response anymore is if... Read more »


Dear Doctor,I really want to ask that if the person really have to be tested at 3 months mark then... Read more »
U.S. Food and Drug Administration

Fourth Generation HIV Diagnostic Test Approved, Permitting Earlier Detection of Infection

On June 18, 2010, FDA approved a new, "4th generation" HIV diagnostic assay. The ARCHITECT HIV Ag/Ab Combo Assay is the first HIV diagnostic assay that simultaneously detects both antigen and antibodies for the Human Immunodeficiency Virus (HIV).... Read more »
HIV i-Base

Third- vs. Fourth-Generation HIV Testing: Almost Half of UK Clinics Out of Step With National Guidelines

In 2011, prompted by calls to the i-Base phoneline reporting wide diversity in the information given to people contacting GUM clinics for HIV testing, i-Base wanted to understand why this was often different to UK guidelines. Although 4th generation... Read more »

The 4th International Workshop on HIV Drug Resistance and Treatment Strategies

The Body Covers: The 4th International Workshop on HIV Drug Resistance and Treatment Strategies Sitges, Spain June 12-16, 2000 Conference Summaries Reports and Related Articles Cal Cohen, M.D. Resistance is one of the most crucial... Read more »
U.S. Centers for Disease Control and Prevention

VA Reports 4th HIV Case Since Dirty Equipment Used

A fourth person who was exposed to unsanitary endoscopy equipment at VA hospitals has tested positive for HIV, the Department of Veterans Affairs said Friday. The department is investigating problems related to equipment-cleaning procedures at its... Read more »
Connect With Others

4th Generation HIV Test

Posted by Trophy

An arsenal of laboratory methods are available to screen blood, diagnose infection, and monitor disease progression in individuals infected by HIV. These tests can be classified into those that: (a) detect antibody, (b) identify antigen, (c) detect... Read more »

Eliza 4th generation

Posted by Anonymous, 1 Reply
The new Eliza 4th generation test tests for both antibodies and the virus itself. I don't know whether its already released to the general public. Anyway, a person testing negative for both after 30 days is considered hiv negative.No further tests... Read more »

3rd or 4th generation elisas?

Posted by Anonymous, 1 Reply
I was wondering if any county health dept. around the country would be using elisas first generation. Is everyone using 3rd or 4th generation? Read more »

4th gen test p24 again

Posted by Anonymous, 3 Replies
seems to me the so called 4th generation test is only good up until 3 weeks after infection. all the research i have done says the p24 antigen test is only good 1-3 weeks after one would have been exposed. so this would mean if i tested at 6 weeks... Read more »