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Unique Collaboration Charts the Migrations of a Parasite that Affected History
Researchers Sequence Louse DNA from Mummies and Propose New Model for its Development


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Featured in U.S. News & World Report
"Common Cold Virus Alters Body's Genes" October 24, 2008
Comparison of the Safety and Immunogenicity of 2 Respiratory Syncytial Virus (RSV) Vaccines— Nonadjuvanted Vaccine or Vaccine Adjuvanted with Alum—Given Concomitantly with Influenza Vaccine to High-Risk Elderly Individuals
Ann R. Falsey, Edward E. Walsh, Jose Capellan, Stefan Gravenstein, Maria Zambon, Eddy Yau, Geoffrey J. Gorse, Robert Edelman, Frederick G. Hayden, Janet E. McElhaney, Kathleen M. Neuzil, Kristen L. Nichol, Eric A. F. Simões, Peter F. Wright, and Valérie M.-P. Sales
A second study, this one published in the Nov. 15 issue of The Journal of Infectious Diseases, found that respiratory syncytial virus, the main cause of lung infections and hospitalizations in children, may actually linger in the body even after symptoms subside.

Featured in Reuters-USE_THIS
"HPV infection rates similar in men and women" October 10, 2008
Age-Specific Prevalence, Incidence, and Duration of Human Papillomavirus Infections in a Cohort of 290 US Men
Anna R. Giuliano, Beibei Lu, Carrie M. Nielson, Roberto Flores, Mary R. Papenfuss, Ji-Hyun Lee, Martha Abrahamsen, and Robin B. Harris
Although men are at high risk of acquiring human papillomavirus (HPV) infections, most last no more than a year, about the same time this sexually transmitted disease persists in women, researchers report in The Journal of Infectious Diseases.

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Honey has been used for thousands of years to help heal wounds. A recent article demonstrated that medical-grade honey kills antibiotic-resistant bacteria (Clinical Infectious Diseases, June 1, 2008). When applied to the forearm, this special Dutch honey (Revamil) kept germs from growing on the skin. The manufacturer also has developed a veterinary formulation called Vetramil, which is supposed to discourage licking.

Featured in Scientific American
"Stomach Bug May Ward Off Asthma" July 16, 2008
Helicobacter pylori Colonization Is Inversely Associated with Childhood Asthma
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"...scientists analyzed data from more than 7,000 participants in a national health and nutrition survey. They found that children between the ages of three and 13 are less than half as likely to have asthma if they carry H. pylori. They also had half the incidence of hay fever and other allergies. The results appear online in the July 15th issue of The Journal of Infectious Diseases."

Featured in U.S. News & World Report
"Stomach Germ May Protect Against Asthma" July 15, 2008
Helicobacter pylori Colonization Is Inversely Associated with Childhood Asthma

Yu Chen, Martin J. Blaser
"A stomach bacterium called Helicobacter pylori may reduce a child's risk of developing asthma by as much as 50 percent, a new study suggests.  H. pylori has been present in the human stomach probably since humans were humans. However, the germ began disappearing over the course of the 20th century with the introduction of antibiotics and cleaner water and homes, perhaps making children more susceptible to asthma, the study authors suggested."

Featured in Wired News
"Internal Bacterial Imbalance Leads to Asthma" July 15, 2008
Helicobacter pylori Colonization Is Inversely Associated with Childhood Asthma
Yu Chen, Martin J. Blaser
"In a study published yesterday in the Journal of Infectious Diseases, researchers showed that Heliobacter pylori, an intestinal microbe that co-evolved with humans, appears to protect children from asthma.  Asthma rates have nearly doubled in the United States since 1970, and are swelling in the developing world. Underlying the rise is a constellation of causes -- and one of these may be the loss of H. pylori, a vanishing member of the rich bacterial ecosystems in our stomachs."

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Duration and Severity of Symptoms and Levels of Plasma Interleukin-1 Receptor Antagonist, Soluble Tumor Necrosis Factor Receptor, and Adhesion Molecules in Patients with Common Cold Treated with Zinc Acetate
Ananda S. Prasad, Frances W. J. Beck, Bin Bao, Diane Snell, and James T. Fitzgerald
Zinc acetate lozenges taken within 24 hours of developing symptoms of the common cold reduce the duration and severity of symptoms, according to a report in The Journal of Infectious Diseases.

Featured in National Public Radio
"Peruvian Mummies' Lice Came from Africa" February 7, 2008
Molecular Identification of Lice from Pre-Columbian Mummies

Didier Raoult, David L. Reed, Katharina Dittmar, Jeremy J. Kirchman, Jean-Marc Rolain, Sonia Guillen, and Jessica E. Light
When humans migrated out of Africa 100,000 years ago, they were likely carrying stowaways. Scientists who've tested head lice taken from Peruvian mummies found the strains of these little parasites were nearly identical to those that were irritating our ancestors in Africa.

Featured in New York Times
"Scientists Say Mummies' Lice Show Pre-Columbian Origins" February 7, 2008
Molecular Identification of Lice from Pre-Columbian Mummies
Didier Raoult, David L. Reed, Katharina Dittmar, Jeremy J. Kirchman, Jean-Marc Rolain, Sonia Guillen, and Jessica E. Light
[In a new paper for the JID, scientists] establish that lice had accompanied their human hosts in the original peopling of the Americas, probably as early as 15,000 years ago. The DNA matched that of the most common type of louse known to exist worldwide now and also before Europeans colonized the New World.

Featured in Reuters
"Head lice came with us out of Africa" February 6, 2008
Molecular Identification of Lice from Pre-Columbian Mummies
Didier Raoult, David L. Reed, Katharina Dittmar, Jeremy J. Kirchman, Jean-Marc Rolain, Sonia Guillen, and Jessica E. Light
Head lice taken from 1,000-year-old mummies in Peru support the idea that the little creatures accompanied humans on their first migration out of Africa, 100,000 years ago, researchers reported on Wednesday.

1 July 2008

Volume 198, Number 1
The Journal of Infectious Diseases 2008;198:51–58
0022-1899/2008/19801-0011$15.00
DOI: 10.1086/588675
MAJOR ARTICLE

Increased Resilience to the Development of Drug Resistance with Modern Boosted Protease Inhibitor–Based Highly Active Antiretroviral Therapy

Viviane D. Lima,1,2

Vikram S. Gill,1,2

Benita Yip,1

Robert S. Hogg,1,3

Julio S. G. Montaner,1,2 and

P. Richard Harrigan1,2

1British Columbia Centre for Excellence in HIV/AIDS, St. Paul's Hospital, and 2Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, and 3Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada

Background.  We explore the temporal and regimen-specific changes of HIV-1 drug resistance in a large cohort of antiretroviral-naive individuals starting highly active antiretroviral therapy (HAART).

Methods.  Individuals ( ) initiating first HAART between August 1996 and November 2004 were followed until November 2005 (median follow-up, 4.8 years; tests). A logistic regression model was used to predict the probability of the emergence of resistance, adjusting for baseline predictors.

Results.  The cohort included 991 individuals initiating nonboosted protease inhibitor (PI)–based regimens, 475 initiating ritonavir-boosted PI–based regimens, and 884 initiating nonnucleoside reverse-transcriptase inhibitor (NNRTI)–based regimens. There was no difference in the development of resistance between nonboosted PI–based regimens (reference group) and NNRTI-based HAART regimens (odds ratio [OR], 1.09 [95% confidence interval {CI}, 0.84–1.42]), but there were greatly reduced odds for boosted PI–based regimens (OR, 0.42 [95% CI, 0.28–0.62]). Individuals initiating HAART more recently (2002–2004) were at a reduced risk of resistance, compared with those who started HAART between 1996 and 1998 (OR, 0.43 [95% CI, 0.30–0.61]).

Conclusions.  Individuals initiating first HAART with a boosted PI–based regimen had a 2.4-fold lower OR for developing HIV drug resistance than did those starting nonboosted PI–based or NNRTI-based HAART, at all adherence levels. The data demonstrate marked temporal improvement in the likelihood of the development of drug resistance for those initiating more recent HAART regimens.

Received 21 August 2007; accepted 13 December 2007; electronically published 22 May 2008.

Reprints or correspondence: Dr. P. Richard Harrigan, Director, Research Laboratories, British Columbia Centre for Excellence in HIV/AIDS, 603-1081 Burrard St., Vancouver, BC, Canada V6Z 1Y6 ().

Cited by

Viviane D Lima, Richard Harrigan, Melanie Murray, David M Moore, Evan Wood, Robert S Hogg, Julio SG Montaner. (2008) Differential impact of adherence on long-term treatment response among naive HIV-infected individuals. AIDS 22:17, 2371-2380
Online publication date: 1-Dec-2008.
CrossRef
  • Potential conflicts of interest: R.S.H., P.R.H., and J.S.G.M. have received honoraria, travel grants to attend conferences, and research grants from pharmaceutical and diagnostic companies working in the area of HIV/AIDS.

    Presented in part: 14th Conference on Retroviruses and Opportunistic Infections, Los Angeles, 25–28 February 2007 (abstract M-195 and poster 614).

    Financial support: Michael Smith Foundation for Health Research (Senior Scholar Award to R.S.H.); Canadian Institutes of Health Research (fellowship to V.D.L.).

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