An Overview of Isentress (Raltegravir, MK-0518)

Brand Name: Isentress
Other Name(s): MK-0518, MK0158, RAL

Drug Class: Integrase Inhibitors

Raltegravir, also known as Isentress and MK-0518, is a type of medicine called an integrase inhibitor. Integrase inhibitors work by blocking integrase, a protein that HIV needs to insert its viral genetic material into the genetic material of an infected cell.

HIV/AIDS-Related Uses

Raltegravir was approved by the FDA on October 12, 2007, for use with other anti-HIV agents in the treatment of HIV infection in adults. It is the first integrase inhibitor approved by the FDA. This medicine does not cure or prevent HIV infection or AIDS and does not reduce the risk of passing the virus to other people.In August 2006, Merck opened a worldwide expanded access program for individuals with HIV who have limited or no treatment options. Individuals and health care professionals can call 1-888-577-8839 or visit www.earmrk.com for more information. Raltegravir was granted traditional approval for use with other anti-HIV agents in the treatment of HIV infection in adults on January 29, 2009.

Dosage Form/Administration

Raltegravir comes in tablet form and is taken by mouth. It can be taken with or without food.

Recommended Daily Dose

The recommended dosage of raltegravir for adults is 400 mg twice a day. Doses of 200, 400, and 600 mg have been studied in clinical trials. An 800 mg dose taken twice a day is recommended for individuals also taking rifampin.Some individuals may benefit from different doses of raltegravir. Individuals should always take raltegravir as prescribed by their doctors.

Contraindications

Individuals should tell a doctor about any medical problems before taking this medicine.

Possible Side Effects

Along with its desired effects, raltegravir can cause some unwanted effects. Although not all of these effects are known, the most common side effects seen in clinical trials have been diarrhea, nausea, headache, and fever. Outside of clinical trials and following approval by the FDA, some people have experienced rash, Stevens-Johnson syndrome, depression, and suicidal tendencies.

Drug and Food Interactions

A doctor should be notified of any other medications being taken, including prescription, nonprescription (over-the-counter), or herbal medications.

Clinical Trials

Click here to search ClinicalTrials.gov for trials that use Raltegravir.

Manufacturer Information

Isentress
Merck & Company, Inc
PO Box 4-ZB-714
West Point, PA 19486
Phone: 800-672-6372

Raltegravir
Merck & Company, Inc
PO Box 4-ZB-714
West Point, PA 19486
Phone: 800-672-6372