Brown Medical School

HIV 101: Antiretroviral Agents Dosing and Administration Recommendations: PIs

January 2002

Adapted from Bartlett J.G. and Gallant J.E. 2001-2002 Medical Management of HIV Infection. Johns Hopkins University, Baltimore, MD. 2001.

This table is a replacement for the table that was printed with a copy error on page 8 of the November 2001 issue of HEPP News. The entire Antiretroviral Agents Dosing and Administration Recommendations table is available in its correct form at www.hivcorrections.org/archives/nov01/nov2001.pdf (pages 7-8) or by emailing a request to heppnews@brown.edu.

Protease Inhibitors (PIs)
	Recommended Dose	Food Effect	Side Effects*
Indinavir (Crixivan)	800 mg q 8h Separated ddI dose by 1 hr	77%; take 1 hr before or 2 hours after meals; may take with low fat snack or skim milk	GI intolerance (10-15%); nephrolithiasis or nephrotoxicity (10-15%); headache; asthenia; dizziness; rash; metallic taste; ITP; alopecia; lab: increase indirect bilirubinemia (inconsequential) Class side effects*
Ritonavir (Norvir)	600 mg bid Separate ddI dose by 2 hr	15%; take with food if possible to improve tolerability	GI intolerance (20-40%); paresthesias-circum-oral and extremities (10%); taste perversion (10%); lab: triglycerides increase in 60% and transaminase increase in 10-15%, CPK and uric acid increase Class side effects*
Saquinavir (Invirase)	Not recommended as single PI 400 mg bid with RTV	No food effect when taken with RTV	GI intolerance (10-20%); increase Class side effects*
Saquinavir (Fortovase)	1,200 mg tid	6x; take with large meal unless taken with RTV	GI intolerance (20-30%); headache; hypoglycermia; transaminase increase Class side effects*
Amprenavir (Agenerase)	1,200 mg bid (caps) 1400 mg bid (oral solution)	High fat meal decreases AUC 20%; can be taken with or without food, but high fat meal should be avoided	GI intolerance (10-30%); rash (20-25% -- usually at 1-10 wks), Stevens-Johnson syndrome (1%); paresthesias (10-30% -- perioral or peripheral) Increase in liver function tests. Class side effects*
Nelfinavir (Viracept)	1,250 mg bid or 750 mg tid	2-3x; take with meal or snack	Diarrhea (10-30%) Class side effects*
Lopinavir + Ritonavir (Kaletra)	3 caps or 0.5 mL twice daily 4 caps bid when used with efavirenz or nevirapine	Fat increases AUC 50% to 80%; should be taken with food	GI intolerance: nausea, vomiting, diarrhea Elevated Lipids Asthenia Class side effects*
* For full information on toxicity and drug interactions for PIs and class side effects, see Chapter 4 of Bartlett J.G. and Gallant J.E. 2001-2002 Medical Management of HIV Infection. Johns Hopkins University, Baltimore, MD. 2001.

Back to the HEPP News January 2002 contents page.

This article was provided by Brown Medical School. It is a part of the publication HEPP News.

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