Print this page    •   Back to Web version of article

Medical News
Combination of Isoniazid, HAART More Effective at Preventing TB in HIV-Positive Patients Than Monotherapy, Study Says

August 16, 2006

A combination of the antibiotic isoniazid and highly active antiretroviral therapy is more effective at preventing active tuberculosis among HIV-positive people than the two treatments on their own, according to a study presented Monday at the XVI International AIDS Conference, Health-e News reports. Richard Chaisson, a professor of infectious diseases at Johns Hopkins University, and colleagues examined the medical records of more than 11,000 HIV-positive adults in Rio de Janeiro, Brazil. The researchers found that the risk of developing TB was reduced by 67% among HIV-positive people who took both isoniazid and HAART, while isoniazid on its own reduced the risk of the disease by 32%, and HAART alone reduced the risk of TB by 51%. The researchers also found that the combination is more beneficial among HIV-positive people with lower CD4+T cell counts. The combination reduced the risk of TB by 66% among HIV-positive people with T cell counts below 350, compared with a 56% risk reduction among HIV-positive people with higher T cell counts, according to the study. Chaisson said although the World Health Organization recommends isoniazid to prevent TB among HIV-positive people and the drug costs less than $1 for a full course of treatment, few physicians prescribe it. The researchers say they plan to continue monitoring the effectiveness of the drugs -- both as a combination therapy and as monotherapies -- at preventing the risk of TB among HIV-positive people in Rio de Janeiro. The research is part of three studies by the Bill & Melinda Gates Foundation-funded Consortium To Respond Effectively to the AIDS/TB Epidemic, which aims to develop new ways to detect and treat TB among HIV-positive people (Thom, Health-e News, 8/13). is serving as the official webcaster of the conference. View the guide to coverage and all webcasts, interviews and a daily video round up of conference highlights at

Back to other news for August 16, 2006

Reprinted with permission from You can view the entire Kaiser Daily HIV/AIDS Report, search the archives, or sign up for email delivery at The Kaiser Daily HIV/AIDS Report is published for, a free service of the Kaiser Family Foundation, by The Advisory Board Company. © 2006 by The Advisory Board Company and Kaiser Family Foundation. All rights reserved.

This article was provided by Henry J. Kaiser Family Foundation. It is a part of the publication Kaiser Daily HIV/AIDS Report. You can find this article online by typing this address into your Web browser:

General Disclaimer: is designed for educational purposes only and is not engaged in rendering medical advice or professional services. The information provided through should not be used for diagnosing or treating a health problem or a disease. It is not a substitute for professional care. If you have or suspect you may have a health problem, consult your health care provider.