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U.S. News

Los Angeles Times Examines Drug Resistance in HIV-Positive People Who Have Undergone Monotherapy

January 20, 2006

The Los Angeles Times on Thursday profiled HIV-positive patients who were treated in the early 1990s using monotherapy, or single-drug treatment, and who often are resistant to antiretroviral combination therapies because they previously have taken one of their components. Monotherapy -- which was used before combination therapy was initiated in 1996 -- gave HIV "only one obstacle to mutate past," and has created a "virtually insurmountable mutational challenge" for researchers to develop effective HIV/AIDS-related therapies, the Times reports. According to the Times, an estimated 40,000 HIV-positive "veterans of monotherapy" in the U.S. are "playing a fearsome waiting game" while researchers "repeatedly improvise with existing medications" to develop "salvage therapy," a "last resort" treatment for monotherapy patients. Salvage therapy "is a machine of many moving parts" because a patient's resistance to a certain drug often means that they are resistant to all other drugs in its class, according to the Times. HIV-positive patients with resistance await new combinations and new classes of drugs such as integrase inhibitors that might offer the chance of a viable treatment (Ricci, Los Angeles Times, 1/19).

Back to other news for January 20, 2006


Reprinted with permission from kaisernetwork.org. You can view the entire Kaiser Daily HIV/AIDS Report, search the archives, or sign up for email delivery at www.kaisernetwork.org/dailyreports/hiv. The Kaiser Daily HIV/AIDS Report is published for kaisernetwork.org, a free service of the Kaiser Family Foundation, by The Advisory Board Company. © 2006 by The Advisory Board Company and Kaiser Family Foundation. All rights reserved.



  
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This article was provided by Henry J. Kaiser Family Foundation. It is a part of the publication Kaiser Daily HIV/AIDS Report. Visit the Kaiser Family Foundation's website to find out more about their activities, publications and services.
 
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