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Lipodystrophy (Body Shape Changes)
Part of An HIVer's Guide to Metabolic Complications

December 2005

What Is Lipodystrophy?

Lipodystrophy is a disturbance in the way the body makes, uses and stores fat. It can result in fat loss or gain in various parts of the body. Sometimes these changes are hard to see, and sometimes they can have a dramatic effect.

There are two types of lipodystrophy:

Doctors first began to notice lipodystrophy in HIV-positive people in the late 1990s, after modern HIV treatment became available -- that is, treatment using a combination of three or more HIV meds. However, there's still a lot of debate over just how much HIV medications are to blame for lipodystrophy.


Testing for Lipodystrophy

Do you feel like, ever since you began HIV treatment, your clothes fit differently, or that specific parts of your body seem bigger or smaller than they used to be? You may be right. Lipodystrophy is real, and your own instincts may be correct. In fact, studies show that your ability to detect changes in the shape of your body is about as good as your doctor's ability to detect those changes using various medical techniques.

So how can you find out whether you have lipodystrophy? If you suspect you have lipodystrophy or before you start taking HIV meds, make sure your doctor measures key parts of your body, such as your arms, legs, neck, belly, waist and thighs, with a nonstretch tape measure. Your doctor may also use a "body fat caliper," which looks sort of like a cross between a ruler and a large, fancy pair of tweezers. By periodically measuring the fat in different parts of your body, you can see whether there have been any changes since you started HIV treatment.

There are plenty of more advanced methods doctors can (and do) use to measure body fat, including expensive, high-tech scans (such as a DEXA scan, an MRI and computed tomography) and electricity-based tests (such as a bioelectric impedance analysis, or BIA). These tests are painless, but they're also generally no more reliable than body fat caliper tests -- or even your own observations. Regardless of the method you use to track your body fat, though, be sure to talk about it with your doctor, preferably before you start taking meds.


Gender Matters

Studies show that men tend to experience fat loss in their arms and legs more than women do, while women may be more likely to see an increase in abdominal (stomach) and breast fat.


Lipodystrophy Buzz Words

Doctors and people with HIV use many different terms to describe certain types of lipodystrophy. Here are some of the more common terms:


Lipodystrophy Myths

It used to be thought that lipodystrophy was a "reshuffling" of the fat in your body -- in other words, the fat in one part of your body would "move" to another part. Research has shown that this is a myth: The fat on your body doesn't rearrange itself. Instead, there are two distinct types of lipodystrophy -- fat loss (lipoatrophy) and fat gain (lipohypertrophy) -- that sometimes can happen in the same person at the same time.


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