Print this page    •   Back to Web version of article

HIV Life Cycle
Protein Synthesis

Newly synthesized viral RNA is transported out of the nucleus and translated, in the case of mRNA, or incorporated into new virions, in the case of genomic RNA. The gag and pol genes are encoded out of a frame on a single mRNA. Frameshifting during the translation of the viral gag-pol messenger RNA, therefore, is essential for the production of pol gene products (protease, reverse transcriptase, and integrase) (1). RNA secondary structure located downstream (3') from the gag/pol frameshift has been shown to be important for wild-type levels of frameshifting to occur (2). Compounds that either inhibit or alter viral mRNA frameshifting are potentially effective antiviral agents.

References

  1. JACKS, T.; POWER, M.D.; MASIARZ, F.R.; LUCIW, P.A.; BARR, P.J.; VARMUS, H.E., Characterization of ribosomal frameshifting in hiv-1 gag-pol expression . NATURE (LONDON) 331:280-283 (1988).
  2. PARKIN, N.T.; CHAMORRO, M., VARMUS, H.E., Human immunodeficiency virus type 1 gag-pol frameshifting is dependent on downstream mrna secondary structure: demonstration by expression in vivo . J VIROL 66(8):5147-5151 (1992).

Back




This article was provided by U.S. National Institute of Allergy and Infectious Diseases. You can find this article online by typing this address into your Web browser:
http://www.thebody.com/content/art6632.html

General Disclaimer: TheBody.com is designed for educational purposes only and is not engaged in rendering medical advice or professional services. The information provided through TheBody.com should not be used for diagnosing or treating a health problem or a disease. It is not a substitute for professional care. If you have or suspect you may have a health problem, consult your health care provider.