Certain viral proteins undergo glycosylation, which has been pursued as a target for possible intervention (1-2). Castanospermine, a naturally occurring alkaloid and inhibitor of glucosidase-I served as a lead compound for the development of analogs. N-Butyl deoxynojirimycin(butyl-DNJ) and 6-butyl-castanospermine represent analogs with more potent activity against HIV (3).
- JOHNSON, V.A.; WALKER, B.D.; BARLOW, M.A.; PARADIS, T.J.; CHOU, T.C.; HIRSCH,
M.S., Synergistic inhibition of human immunodeficiency virus type 1 and type 2 replication in vitro
by castanospermine and 3'-azido-3'-deoxythymidine
. ANTIMICROB AGENTS CHEMOTHER 33:53-57 (1989).
- RUPRECHT, R.M.; MULLANEY, S.; ANDERSEN, J.; BRONSON, R., In vivo analysis of castanospermine, a
candidate antiretroviral agent
. J AIDS 2:149 (1989).
- SUNKARA, P.S., TAYLOR, D., KANG, M., BOWLIN, T., LIU, P., TYMS, A.,
SJOERDSMA, A. Anti-HIV activity of castanospermine analogs. LANCET, 1989;1:1206 (1989).