HIV Life Cycle
Certain viral proteins undergo glycosylation, which has been pursued as a target for possible intervention (1-2). Castanospermine, a naturally occurring alkaloid and inhibitor of glucosidase-I served as a lead compound for the development of analogs. N-Butyl deoxynojirimycin(butyl-DNJ) and 6-butyl-castanospermine represent analogs with more potent activity against HIV (3).
This article was provided by U.S. National Institute of Allergy and Infectious Diseases.