HIV Life Cycle
Although HIV replicates extensively throughout all stages of infection (1-2), latently infected cells do exist (3) and if viral eradication is to be achieved it is essential to develop agents to target these cells. The advent of potent anti-viral therapy has demonstrated that the vast majority of HIV viral production is due to newly infected cells and not the activation of latently infected cells (1-2).
Although there may still be important therapeutic roles for compounds capable of inducing viral latency (4), potent anti-HIV therapies have raised the prospect of viral eradication, a goal inconsistent with the induction of viral latency. Since HIV expression in nearly all primary cells appears to be cytopathic, compounds capable of inducing viral activation or preventing latency combined with potent anti-HIV therapies may represent a strategy capable of eradicating HIV.
This article was provided by U.S. National Institute of Allergy and Infectious Diseases.