NIH Announces New International Network to Study HIV Prevention Strategies
July 12, 2000
The U.S. National Institutes of Health (NIH) today announced the formation of the international HIV Prevention Trials Network (HPTN) to develop and test promising non-vaccine strategies to prevent the spread of HIV/AIDS. The global initiative will explore alternative measures, besides AIDS vaccines, that may be able to block or reduce infection with HIV. The HPTN will constitute NIH's largest comprehensive multicenter network dedicated to this task, comprising core operational, data and laboratory centers, as well as research sites located worldwide in Africa (Malawi, South Africa, Tanzania, Uganda, Zambia and Zimbabwe), Asia (China, India and Thailand), Europe (Russia), South America (Peru) and the United States.
"We must investigate all potential strategies to stop HIV transmission, including microbicides and other biomedical and behavioral interventions," says Anthony S. Fauci, M.D., director of the National Institute of Allergy and Infectious Diseases (NIAID), the network's lead sponsor. "The HPTN strengthens our capability to discover new and better measures to protect people, especially children and women, from HIV infection."
Along with NIAID, other NIH components co-sponsoring the HPTN include the National Institute of Child Health and Human Development, the National Institute of Mental Health and the National Institute on Drug Abuse. Funding for the first year of the project totals slightly over $30 million.
HPTN studies will focus on six key areas of prevention research:
Previously, NIAID's HIV prevention research program was centered in the HIV Network for Prevention Trials (HIVNET), made up of domestic and international organizations. HIVNET investigators competed with other scientists worldwide in applying for inclusion in the HPTN through a peer-reviewed evaluation process.
"HIVNET's studies set a high standard of scientific and medical excellence from which the HPTN will evolve and expand into new areas," explains Jack Killen, M.D., director of NIAID's Division of AIDS. HIVNET researchers achieved several breakthrough discoveries, such as demonstrating the effectiveness of a simple regimen, using the low-cost drug nevirapine, to prevent mother-to-infant HIV infection. Another HIVNET study identified viral load in a person's blood as a critical factor governing the likelihood of heterosexual HIV transmission, suggesting that strategies which lower this level may play a role in prevention. "The HPTN will include many of the most experienced and talented HIV prevention experts around the world."
The hub of the new network comprises 1) the Core Group/Operations Center, led by Ward Cates, M.D., M.P.H., of Family Health International in North Carolina's Research Triangle Park; 2) the Central Laboratory, headed by Johns Hopkins University investigator Brooks Jackson, M.D., in Baltimore; and 3) the Statistical and Data Coordinating Center, led by Thomas Fleming, Ph.D., of the Fred Hutchinson Cancer Research Center in Seattle.
According to Dr. Cates, "The HPTN establishes a strong foundation of scientific collaboration among the world's leaders in HIV prevention research. This will be an exciting environment in which we can do truly progressive studies with a potential public health impact worldwide."
The following investigators will lead the U.S. sites participating in the HPTN:
ALABAMAThe following investigators will lead the international sites participating in the HPTN:
PERUIn addition, NIAID anticipates establishing a site in Brazil within the next few months.
NIAID conducts and supports research to prevent, diagnose and treat illnesses such as HIV disease and other sexually transmitted diseases, tuberculosis, malaria, asthma and allergies. NIH is an agency of the U.S. Department of Health and Human Services.
Press releases, fact sheets and other NIAID-related materials are available on the NIAID Web site at http://www.niaid.nih.gov.
This article was provided by U.S. National Institute of Allergy and Infectious Diseases.