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An Overview of Edurant (Rilpivirine)

August 23, 2013

Brand Name: Edurant
Other Name(s): RPV, rilpivirine hydrochloride
Drug Class: Non-nucleoside Reverse Transcriptase Inhibitors
Approved Use: Treatment of HIV Infection

WARNING:

Rilpivirine can cause serious, life-threatening side effects. These include depression, mood changes, and liver problems.

Contact your health care provider right away if you have any of the following symptoms of depression or mood changes:

Hepatoxicity, which is a serious liver problem, has occurred in some people taking rilpivirine, including a few people with no prior liver disease or other risk factors for liver problems. People taking rilpivirine should be monitored for liver problems before starting rilpivirine and during treatment with rilpivirine.

While taking rilpivirine, it is important to keep all of your appointments with your health care provider.


What is rilpivirine?

Rilpivirine is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in adults who have never taken HIV medicines before and who have a viral load (number of HIV RNA copies per mL of blood) of 100,000 copies/mL or less at the start of treatment. Rilpivirine is always used in combination with other anti-HIV medicines.

Rilpivirine is a type of anti-HIV medicine called a non-nucleoside reverse transcriptase inhibitor (NNRTI). NNRTIs work by binding to and blocking HIV reverse transcriptase, an HIV enzyme. This prevents HIV from replicating and lowers the amount of HIV in the blood.

Rilpivirine does not cure HIV/AIDS. It is not known if rilpivirine reduces the risk of passing HIV to other people.


What should I tell my health care provider before taking rilpivirine?

Before taking rilpivirine, tell your health care provider:


How should I take rilpivirine?

Rilpivirine comes in one form:

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Take rilpivirine according to your health care provider's instructions.

Always take rilpivirine with a meal. (A protein drink alone does not replace a meal.)

Always take rilpivirine in combination with other anti-HIV medicines.

If you take too much rilpivirine, contact your local poison control center (1-800-222-1222) or go to the nearest hospital emergency room right away.

For more information on how to take rilpivirine, see the FDA drug label from DailyMed. (DailyMed is a federal website that includes the most recent drug labels submitted to FDA.)


What should I do if I forget a dose?

If you miss a dose of rilpivirine within 12 hours of the time you usually take it, take your dose with a meal as soon as possible. Then take your next dose at the regularly scheduled time. If you miss a dose by more than 12 hours from the time you usually take it, wait and then take the next dose at the regularly scheduled time.


What side effects can rilpivirine cause?

Rilpivirine can cause serious, life-threatening side effects. These include depression or mood changes. (See the WARNING above.)

Other possible side effects of rilpivirine include:

Tell your health care provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of rilpivirine. Ask your health care provider or pharmacist for more information on possible side effects of rilpivirine.


How should rilpivirine be stored?


Where can I find more information about rilpivirine?

More information about rilpivirine is available:


Manufacturer Information

Janssen Pharmaceuticals, Inc.
800-526-7736




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