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Women, Hormones and HIV

January 2013

Table of Contents


Hormone Basics

Hormones are chemicals in your body that are carried in your blood stream and send messages between different organs. They are formed in glands and organs, and they control all sorts of processes in the body. Hormones have an effect on your growth, metabolism (your body's chemical processes), sex drive, and ability to have children.


Hormones and HIV

Studies have shown that HIV can affect the body's ability to make hormones and keep healthy hormone levels. There are many types of hormones. The hormones that seem to be particularly affected by HIV are the following:

Estrogen, progesterone, testosterone, and DHEA levels naturally get lower as you age. Changes in one of these hormones can affect the levels of the others.

Some drugs that are used to treat HIV-related conditions can also affect hormone levels. These include:

Experts believe that hormones (especially growth hormone) are also connected to wasting and lipodystrophy, a group of fat-related body changes that appear in some people living with HIV (HIV+). However, more research is needed in this area.


Problems Caused by Irregular Hormone Levels

Changes in your hormone levels can affect many of your body's functions. Some of the symptoms that are caused by hormone level changes include:

If you are experiencing any of these symptoms, it is important that you see your health care provider, who can check your hormone levels and address any problems.

HIV+ women who experience sweats at night may be misdiagnosed as having menopause-related hot flashes, when in fact their sweats may be the result HIV infection and related conditions such as "wasting." Vaginal dryness can be mistaken for a yeast infection. It is important to keep track of your cycles and report anything unusual to your health care provider so that you can find the cause of your symptoms. For more information about menstrual problems and HIV, see TWP's info sheet, Menstrual Changes.


Hormone Replacement Therapy (HRT)

Women who have low estrogen levels may choose to replace the estrogen in order to regulate menstrual periods and help relieve pre-menstrual syndrome (PMS). However, the most common reason to replace estrogen is to relieve the symptoms of menopause.

Care must be taken in replacing estrogen. Taking estrogen without progesterone increases the risk of uterine cancer. If a woman's uterus (womb) has been removed, she can take estrogen by itself. This is called estrogen replacement therapy or ERT.

Women who still have a uterus usually take a combination of estrogen and progesterone. This is called hormone replacement therapy (HRT).

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Although HRT used to be regularly recommended to relieve menopausal symptoms and reduce bone loss, long-term use of HRT is now questionable. Research has shown that HRT can increase women's risk for breast cancer, heart disease, and stroke. HRT may be appropriate for a short time to relieve menopausal symptoms that do not respond to other therapies. Estrogen and progesterone are available in patches, creams, and vaginal rings; these may be an alternative to the pill form of HRT and may not carry the same risks.

To figure out if HRT is right for you, speak with your health care provider about all the risks and benefits. When deciding about HRT, it is important to tell your provider about any drugs or other treatments you are taking. HIV drugs can sometimes reduce the effectiveness of hormones, including birth control pills containing estrogen and progesterone. Estrogen can also cause decreased levels of HIV drugs and put you at risk for a rising viral load and HIV drug resistance.


Alternative Treatments

There are other therapies available to treat menopausal symptoms. However, these may also have unwanted side effects or interact with HIV drugs. If you choose alternative therapies it is best to consult a skilled practitioner and let your regular health care provider know exactly what you are doing.

Other treatments may include:


Testosterone

Shortages of testosterone can result in fatigue, sexual problems, depression, and muscle loss. Many women who take testosterone or anabolic steroids report improved energy, sex drive, mood, and better quality of life. Anabolic steroids are drugs with very similar effects as testosterone. They have also been shown to increase lean muscle mass and add weight.

Speak to your health care provider about possible side effects from testosterone use. Women may experience facial hair growth, deepening of their voice, or clitoral enlargement. Testosterone is available in many forms; patches, gels, and creams may be preferred to injections and tablets because they decrease the likelihood side effects listed above. Testosterone is not recommended for women who are pregnant or who wish to become pregnant.


Human Growth Hormone

Women suffering from weight loss (wasting) or lipodystrophy may consider treatment with human growth hormone (HGH, Serostim). HGH has been shown to increase lean muscle mass and may reduce fat changes associated with lipodystrophy. Unfortunately, HGH does not seem to correct facial wasting. Because of its high cost and potential side effects (e.g., high cholesterol, muscle and joint pain, swelling due to fluid retention), HGH is not for everyone.


Taking Care of Yourself

Discuss any symptoms you are experiencing with your health care provider. If a hormone imbalance is found to be the cause, you can explore treatment options. Also make sure to discuss drug interactions and long-term side effects of hormone use.




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