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Preparing for Pre-Exposure Prophylaxis

Spring 2011

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Answering the Call for Comprehensive HIV/AIDS Prevention

The implementation of PrEP will not be simple. Maximizing PrEP's public health benefit will require a comprehensive approach that involves the coordinated efforts of service providers in clinical and non-clinical settings. If we are unprepared to address the issues that PrEP raises, an important opportunity to reduce new infections in Canada may be lost and a host of new problems created.

For years, there have been calls from experts in HIV prevention demanding that our prevention efforts adopt a more comprehensive approach that combines different behavioural, structural and biomedical interventions.8 With the possible introduction of partially protective biomedical technologies, such as PrEP, we are entering a new era in HIV/AIDS prevention in which the need for a comprehensive approach is even more immediate and pressing.


Strategies for Using Pre-Exposure Prophylaxis (PrEP) to Lower HIV Incidence in Select Populations -- Policy Considerations and Suggestions of the National PrEP Committee: Project Inform, AIDS Vaccine Advocacy Coalition, Community HIV/AIDS Mobilization Project, National Alliance of State & Territorial AIDS Directors. December 1, 2010.

Interim Guidance: Preexposure Prophylaxis for the Prevention of HIV Infection in Men Who Have Sex With Men -- Centers for Disease Control and Prevention (CDC)

James Wilton is the project coordinator of the Biomedical Science of HIV Prevention Project at the Canadian AIDS Treatment Information Exchange (CATIE). James has an undergraduate degree in microbiology and immunology from the University of British Columbia.


  1. Cates W. After CAPRISA 004: time to re-evaluate the HIV lexicon. Lancet. 2010 Aug 14;376(9740):495-496.
  2. Abdool Karim Q, Abdool Karim SS, Frohlich JA, et al. Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women. Science. 2010 Sep 3;329(5996):1168-1174.
  3. Grant RM, Lama JR, Anderson PL et al. Preexposure chemoprophylaxis for HIV prevention in men who have sex with men. New England Journal of Medicine. 2010 Nov 23;(Epub ahead of print).
  4. Underhill K, Operario D, Skeer MR, Mimiaga MJ, Mayer KH. Packaging PrEP to prevent HIV: An integrated framework to plan for pre-exposure prophylaxis implementation in clinical practice. Journal of Acquired Immune Deficiency Syndromes. 2010 9;55(1):8-13.
  5. Grohskopf L, Gvetadze R, Pathak S et al. Preliminary analysis of biomedical data from the phase II clinical safety trial of tenofovir disoproxil fumarate (TDF) for HIV-1 pre-exposure prophylaxis (PrEP) among US men who have sex with men (MSM). XVIII International AIDS Conference. 2010 Jul 18;Abstract FRLBC102.
  6. Peterson L, Taylor D, Roddy R, Belai G, Phillips P, Nanda K, et al. Tenofovir disoproxil fumarate for prevention of HIV infection in women: a phase 2, double-blind, randomized, placebo-controlled trial. Public Library of Science Clinical Trials. 2007;2(5):e27.
  7. Nguyen V, Bajos N, Dubois-Arber F et al. Remedicalizing an epidemic: from HIV treatment as prevention to HIV treatment is prevention. AIDS. 2010 Dec 9;(Epub ahead of print).
  8. Rotheram-Borus MJ, Swendeman D, Chovnick G. The past, present, and future of HIV prevention: integrating behavioural, biomedical, and structural intervention strategies for the next generation of HIV prevention. Annual Review of Clinical Psychology. 2009;5:143-167.
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This article was provided by Canadian AIDS Treatment Information Exchange. It is a part of the publication Prevention in Focus: Spotlight on Programming and Research. Visit CATIE's Web site to find out more about their activities, publications and services.
See Also
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