February 9, 2012
Nelfinavir also fights some types of cancer. It has been studied against breast cancer and anal cancer.
There are no absolute rules about when to start ART. You and your health care provider should consider your CD4 cell count, your viral load, any symptoms you are having, and your attitude about taking ART. Fact Sheet 404 has more information about guidelines for the use of ART.
If you take nelfinavir with other ARVs, you can reduce your viral load to extremely low levels, and increase your CD4 cell counts. This should mean staying healthier longer.
Fact Sheet 126 for more information on resistance.
Sometimes, if your virus develops resistance to one drug, it will also have resistance to other ARVs. This is called "cross-resistance."
Resistance can develop quickly. It is very important to take ARVs according to instructions, on schedule, and not to skip or reduce doses.
Late in 1999, the FDA approved twice-daily dosing of nelfinavir at 1250 mg per dose. This meant taking 5 capsules at a time. In April 2003 the FDA approved a 625 mg tablet. This cut the pill count to 2 tablets, twice a day.
If you want to change how often you take nelfinavir, talk to your health care provider. Different doses are used in some combinations. Be sure you know how much nelfinavir your health care provider has prescribed for you, and when and how to take each dose.
Nelfinavir should be stored at room temperature and protected from moisture, freezing, or excessive heat.
Drugs to watch out for include other ARVs, drugs to treat tuberculosis (see Fact Sheet 518), for erectile dysfunction (such as Viagra), for heart rhythm (antiarrhythmics), and for migraine headaches. Interactions are also possible with several antihistamines (allergy medications), sedatives, drugs to lower cholesterol, and anti-fungal drugs. Make sure that your health care provider knows about ALL drugs and supplements you are taking.
If you are taking nelfinavir and ddI, you should take ddI one hour before or two hours after nelfinavir.
Nelfinavir decreases blood levels of Kaletra and can affect levels of Warfarin, used to adjust blood clotting.
Taking nelfinavir with delavirdine increases blood levels of both drugs. Avoid this combination.
Nelfinavir decreases methadone levels. Watch for signs of excessive sedation if you take nelfinavir with buprenorphine.
Some birth control pills may not work if you are taking nelfinavir. Talk to your health care provider about how to prevent an unwanted pregnancy.