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Fact Sheet

Drug Names and Manufacturers

September 23, 2013

  1. Reverse Transcriptase Inhibitors ("Nukes")
  2. Non-Nucleoside Reverse Transcriptase Inhibitors
  3. Protease Inhibitors
  4. Integrase Inhibitors
  5. Attachment and Fusion Inhibitors


None of these drugs can kill the HIV virus, but each class slows down the multiplication of the virus (replication) in a particular way.

Combination medications: Some manufacturers have combined more than one drug into a single tablet or capsule. Combinations within a single class are listed below. Combinations of more than one type of drug are discussed in Fact Sheet 470.


1. Reverse Transcriptase Inhibitors ("Nukes")

The first anti-HIV drugs. They block reverse transcription (the creation of viral DNA from RNA) by providing "decoy" building blocks that interrupt the process. Most are nucleoside analogs; tenofovir is a nucleotide analog.

Year
Approved*
Generic Name Trade Name Also Known As: Manufacturer
1987 Zidovudine Retrovir AZT, ZDV ViiV Healthcare & generic
1991 Didanosine Videx ddI Bristol-Myers Squibb & generic
1992 Zalcitabine Hivid ddC,
dideoxycytidine
Roche: Manufacture discontinued in 2006
1994 Stavudine Zerit d4T Bristol-Myers Squibb & generic
1995 Lamivudine Epivir 3TC ViiV Healthcare & generic
1997 Zidovudine/ lamivudine Combivir Combines AZT
and 3TC
ViiV Healthcare & generic
1998 Abacavir Ziagen ABC ViiV Healthcare & generic
2000 Zidovudine/ lamivudine/ abacavir Trizivir Combines AZT, 3TC, abacavir ViiV Healthcare
2001 Tenofovir Viread TDF Gilead Sciences & generic
2003 Emtricitabine Emtriva FTC Gilead Sciences & generic
2004 Abacavir/lamivudine Epzicom Combines Ziagen and 3TC ViiV Healthcare & generic
2004 Emtricitabine/tenofovir Truvada Combines Emtriva and Viread Gilead Sciences & generic


2. Non-Nucleoside Reverse Transcriptase Inhibitors

These also interrupt reverse transcription, by binding to the reverse transcriptase enzyme and restricting its activity.

Year
Approved*
Generic Name Trade Name Also Known As: Manufacturer
1996 Nevirapine Viramune NVP Boehringer Ingelheim & generic
1997 Delavirdine Rescriptor DLV ViiV Healthcare
1998 Efavirenz Sustiva,Stocrin EFV Bristol-Myers Squibb & generic
2008 Etravirine Intelence ETR Tibotec
2011 Rilpivirine Edurant RPV Tibotec


3. Protease Inhibitors

Block the action of protease, an enzyme that cuts HIV protein chains into specific proteins needed to assemble a new copy of the virus. NOTE: when you see "/r" after the name of a protease inhibitor, that means it is boosted with a small dose of ritonavir. For example, SQV/r means saquinavir boosted with ritonavir. At present, only lopinavir and ritonavir are available in a single pill.

Year
Approved*
Generic Name Trade Name Also Known As: Manufacturer
1995 Saquinavir Invirase SQV Roche
1996 Ritonavir Norvir RTV Abbott
1996 Indinavir Crixivan IDV Merck
1997 Nelfinavir Viracept NFV ViiV Healthcare
1997 Saquinavir Fortovase; Manufacture discontinued in 2006 Roche
1999 Amprenavir Agenerase; Manufacture discontinued in 2007 ViiV Healthcare
2000 Lopinavir/ritonavir Kaletra, Aluvia LPV Abbott & generic
2003 Atazanavir Reyataz®™ ATV Bristol-Myers Squibb
2003 Fosamprenavir Lexiva®™, Telzir FPV ViiV Healthcare
2005 Tipranavir Aptivus TPV Boehringer Ingelheim
2006 Darunavir Prezista DRV Tibotec


4. Integrase Inhibitors

Block the action of integrase, an enzyme that inserts the viral DNA into the infected cell's DNA strands.

Year
Approved*
Generic Name Trade Name Also Known As: Manufacturer
2007 Raltegravir Isentress RGV Merck
2012 Elvitegravir None yet, part of Stribild EVG Gilead
2013 Dolutegravir Tivicay DTG Viiv Healthcare


5. Attachment and Fusion Inhibitors

Prevent HIV from attaching to a cell.

Year
Approved*
Generic Name Trade Name Also Known As: Manufacturer
2003 Enfuvirtide Fuzeon T-20 Trimeris/Roche
2007 Maraviroc Selzentry, Celsentri MVC ViiV Healthcare


*Year of approval in the U.S.A. Many generic versions have been approved under the President's Emergency Plan for AIDS Relief. See www.fda.gov/oia/pepfar.htm for more information.



  
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This article was provided by AIDS InfoNet. Visit AIDS InfoNet's website to find out more about their activities and publications.
 
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