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Aging and HIV

November 27, 2015

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Aging and HIV

Table of Contents

The Aging HIV Population Is Growing

Worldwide, more than four million people 50 years and older are living with HIV (HIV+). According to UNAIDS, the proportion of older adults living with HIV continues to increase in all regions. For the first time since the HIV pandemic began, more than one in ten adults living with HIV is 50 or over in low- and middle-income countries. In high-income countries, approximately three in ten adults living with HIV are 50 or over.

In the US, HIV began mostly as a disease of young men, but today the epidemic impacts people of all ages, including older people (age 50 and over). While 50 may not seem 'old,' it is often the age currently used by organizations that keep track of health-related statistics (e.g., the US Centers for Disease Control and Prevention, or CDC). As a result, issues related to getting and being older with HIV are receiving more and more attention as this population grows.

The aging population of people living with HIV is growing for two reasons: 1) powerful HIV drugs are allowing many people living with to live into their 50s and beyond; and 2) while most new HIV infections occur in younger people, people 50 and older are being infected at increasing rates. The CDC reports that one in four adults living with HIV was 50 and older in the US in 2012.

Many of the medical problems facing people living with HIV now have more to do with diseases of aging than HIV-related illnesses. More middle-age and older people living with HIV are experiencing medical problems related to aging. Research shows that almost two-thirds of deaths among people living with HIV are currently the result of non-AIDS-related causes.

Living and Aging With HIV

Recent advancements in HIV drugs have been successful at keeping people's immune systems healthy with fewer side effects and fewer pills. Despite the tremendous improvements in HIV drugs that now enable most people living with HIV to live long and healthy lives, there are several ways in which living and aging with HIV are different compared to aging while HIV-negative. Some of the health problems of older people appear to happen earlier and faster in people living with HIV (this is sometimes referred to as "accelerated aging").

Scientists are not sure why this happens. It may be that simply being infected with the virus leads to many of the chronic medical conditions associated with aging. HIV infection decreases the ability of the immune system to fight off infections; this is often referred to as the immune system being suppressed. However, because the immune system of a person living with HIV is always struggling to get rid of the virus, the immune system of people living with HIV is always activated, or "turned on." After many years of being constantly activated, the immune system of people living with HIV may show signs of premature aging.

In addition, an activated immune system produces inflammation. Ongoing inflammation appears to be related to many conditions, including heart disease and cancer. Scientists are still exploring whether people living with HIV experience 'accelerated aging' as a result of being HIV+.

The drugs used to treat HIV may also contribute to the aging-related health conditions seen in people living with HIV. Although the HIV drugs used now are more effective and less toxic than in previous years, they still may have long-term effects that we do not yet fully understand.

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This article was provided by The Well Project. Visit The Well Project's Web site to learn more about their resources and initiatives for women living with HIV. The Well Project shares its content with to ensure all people have access to the highest quality treatment information available. The Well Project receives no advertising revenue from or the advertisers on this site. No advertiser on this site has any editorial input into The Well Project's content.


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