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Lipids are fats and fat-like substances in the blood. Cholesterol and triglycerides are lipids. Your body uses cholesterol to build and maintain cells and to make some hormones. After eating, energy that is not needed right away is converted into triglycerides, which are stored in fat cells.
While having some cholesterol and triglycerides in the blood is important for the body to function properly, having too much is unhealthy. Having high levels of lipids is called hyperlipidemia.
There are many possible causes for high lipid levels, including HIV and some of the HIV drugs. This puts people living with HIV (HIV+) at particular risk for developing hyperlipidemia. Although you cannot tell if you have this condition without lab tests, it can cause serious long-term health problems.
The main danger of hyperlipidemia is heart disease. If you have too much cholesterol in your blood it can build up on the inside of your arteries (blood vessels), and form plaques. This buildup of plaque can lead to a heart attack or a stroke. High triglycerides can also increase your risk of getting pancreatitis (a painful inflammation of an organ in your abdomen called the pancreas).
Some HIV+ people experience lipodystrophy. Lipodystrophy means abnormal body fat changes, and can include body shape changes and metabolic changes like hyperlipidemia. These changes have been linked to increased chances of developing diabetes, heart disease, and strokes. (For more info, see TWP sheets on lipodystrophy).
There are two main kinds of cholesterol. One is low-density lipoproteins (LDL) or "bad" cholesterol, which can clog the arteries. The higher your LDL, the higher your risk of heart disease. The other kind is high-density lipoproteins (HDL) or "good" cholesterol, which can help reduce the risk of heart disease.
Your health care provider can tell you if you have high cholesterol or triglycerides by doing a simple blood test called a fasting lipid profile. This will measure total cholesterol, HDL, LDL, and triglycerides. It is important that you have nothing to eat or drink for eight to 12 hours before the test is done. The following levels are ideal:
There are several types of fat found in the foods we eat. These include saturated fats, trans fats, polyunsaturated fats, and monounsaturated fats. Saturated and trans fats raise cholesterol and increase the risk of heart disease the most. They are considered "bad" fats. Polyunsaturated and monounsaturated fats tend to keep cholesterol low and are considered to be "good" fats.
Saturated fat is usually solid at room temperature (e.g., butter). It is found in the fat of animal products like meats and dairy. It is also found in a few vegetable products like coconut, palm, and palm kernel oil. To keep your intake of saturated fat low, check food labels and choose dairy products with low fat content like skim (non-fat) or one percent milk, and low fat cheese and ice cream. When you are buying meats, choose leaner cuts of meat and trim off fat before cooking. Lean meat has less visible 'marbling' (white fatty swirls or stripes that can be seen in the pinkish meat). If you have any questions, ask your grocer or butcher to help you find leaner cuts of meat.
Most trans fats are industrial or synthetic fats. These are the result of food processing techniques that partially hydrogenate unsaturated fats. To reduce how much trans fat you eat, check food labels for trans fat and any partially hydrogenated oils.
Polyunsaturated and monounsaturated fats ("good" fats) are usually liquid at room temperature and generally have plant-based sources. These include oils (olive oil, safflower oil, peanut oil), nuts, and avocados. If you use oil in cooking, the two best choices are canola and olive oil.
Eating a lot of "refined" carbohydrates or simple sugars (e.g. sugary foods, sodas, white bread, white rice) can raise triglycerides. If you need to reduce total cholesterol, LDL, and triglyceride levels it is important to limit the amount of bad fats and excess sugar in your diet. See a registered dietitian to help you make good choices and plan your meals. Many AIDS service organizations have registered dietitians on staff who will see you free of charge. For more information, see TWP's sheet on nutrition.
Aerobic, or cardiovascular exercise, is the kind of physical activity that will help lower your lipid levels. A brisk walk, or other activity that gets your heart pumping moderately hard counts as aerobic exercise that can benefit your heart. This kind of exercise has been found to lower total cholesterol, triglycerides, and LDL; it can also raise HDL. Try to get 20 to 30 minutes of aerobic exercise three to five times a week.
Sometimes, despite diet and exercise, lipids cannot be kept at healthy levels without the help of drugs. There are a variety of drugs available to help lower cholesterol and triglycerides. Some of these may interact with HIV drugs. To reduce the chance of drug interactions, make sure your health care provider is aware of all the medications you take.
If you take a lipid-lowering drug, it is still important to include a good diet and exercise in your lifestyle to help the drug work its best. It is also important to take the drug consistently.
Some HIV drugs have been:
While experts agree that heart disease risks are associated with some HIV medications, there are also important benefits to the heart and immune system from HIV treatment. It is important to work with your health care provider to weigh the risks and benefits of the HIV medications you choose.
There are some HIV drugs that have less of an impact on cholesterol and triglycerides. These include Edurant (rilpivirine), Viramune (nevirapine), Intelence (etravirine), Isentress (raltegravir), and Selzentry (maraviroc). Reyataz (atazanavir) and Prezista (darunavir) are also less likely to increase lipids, but both require use with Norvir (ritonavir), and Norvir does increase lipids.
If you take HIV drugs, be aware of the possible side effects. Get monitored at regular medical check ups for high lipid levels. Do not stop or make changes to your HIV drug regimen without speaking to your health care provider.
Other factors that increase a person's risk of heart disease include:
Try these tips for lowering cholesterol and triglycerides and decreasing other risk factors:
If you have hyperlipidemia, it is especially important to take care of your body. Keep all of your medical appointments, get regular lab tests, and tell your health care provider about any changes in the way you feel or in your body shape.
Hyperlipidemia and other conditions associated with lipodystrophy have been linked with heart disease and strokes in HIV+ people, so make sure you are monitored closely. Other factors also contribute to the risk of heart attacks and strokes, including high blood pressure. If you have high blood pressure, make sure it is treated. You can also support your body, and especially your heart, with a healthy diet, regular exercise, and limiting or stopping tobacco use.