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HIV Drug Chart/Overview

May 2012

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Protease Inhibitors (PIs)

Aptivus

Brand Name: Aptivus
Other Name(s):TPV
Generic Name(s):Tipranavir
Class of Drug:PI
Common Side Effects:Nausea, vomiting, diarrhea, stomach pain, fatigue, headaches
Serious Side Effects:Liver problems, lipodystrophy, increased cholesterol and triglycerides, sulfa allergy, high blood sugar, internal bleeding, Stevens-Johnson syndrome (severe skin rash accompanied by fever, fatigue, muscle or joint aches, blisters, facial and tongue swelling)
Special Considerations:Should not be taken by people with moderate-to-severe hepatitis B or C
Pregnancy:No information in human pregnancy
Women-Specific Information:Because Aptivus reduces the levels of some hormonal contraceptives, talk to your health care provider about changing to or adding other methods of contraception if you take Aptivus. Skin rash is a more common side effect in women taking birth control pills or hormone replacement therapy.
Who Produces the Drug:Boehringer Ingelheim
Web Site for Drug Info:www.aptivus.com
Patient Assistance:Aptivus Patient Assistance Program or 1-800-556-8317
No co-payment assistance is available

Crixivan

Brand Name: Crixivan
Other Name(s):IDV
Generic Name(s):Indinavir
Class of Drug:PI
Common Side Effects:Nausea, vomiting, diarrhea, stomach pain, heartburn, headaches, fatigue, trouble sleeping, rash, dry or itchy skin, hair loss, back pain
Serious Side Effects:Kidney stones (drink 8 glasses of water daily to lower risk of kidney stones), hemolytic Anemia (destruction of red blood cells), lipodystrophy, increased cholesterol and triglycerides, high blood sugar, jaundice (yellowing of the skin and eyes), increased bleeding in people with hemophilia
Special Considerations:Do not take Crixivan with grapefruit juice
Pregnancy:No evidence of increased birth defects. There is some concern about Crixivan's effect on infant liver health. Use of Crixivan without Norvir during pregnancy is not recommended.
Women-Specific Information:Some studies suggest that women taking Crixivan are more likely than men to develop kidney problems
Who Produces the Drug:Merck
Web Site for Drug Info:Crixivan
Patient Assistance:Reimbursement Support Program
1-800-850-3430
No co-payment assistance is available

Invirase

Brand Name: Invirase
Other Name(s):SQV
Generic Name(s):Saquinavir
Class of Drug:PI
Common Side Effects:Nausea, diarrhea, stomach pain, gas, headaches, fatigue, trouble sleeping, mental confusion
Serious Side Effects:lipodystrophy, high blood sugar, increased cholesterol and triglycerides, increased bleeding in people with hemophilia, jaundice (yellowing of the skin and eyes), increased risk of developing abnormal heart rhythms
Special Considerations:Another version of this drug called Fortovase was discontinued in the US in 2006, but is still used in other countries. Invirase is the only version available in the US.
Pregnancy:No evidence of increased birth defects. Evidence shows that Invirase + Norvir is safe in the short-term for mothers and infants.
Women-Specific Information:Because Invirase reduces the levels of some hormonal contraceptives, talk to your health care provider about changing to or adding other methods of contraception if you take Inverase
Who Produces the Drug:Genentech (Roche)
Web Site for Drug Info: Invirase
Patient Assistance: Genentech's patient assistance program: RxAssist
1-877-757-6243
No co-payment assistance available


Kaletra

Brand Name: Kaletra (Aluvia in some countries outside the US)
Other Name(s):LPV/r
Generic Name(s):Lopinavir plus ritonavir (combined in the same tablet)
Class of Drug:PI
Common Side Effects:Nausea, vomiting, diarrhea, stomach pain, headaches, fatigue, weakness, heartburn
Serious Side Effects:Liver problems, pancreatitis, lipodystrophy, increased cholesterol and triglycerides, high blood sugar, increased bleeding in people with hemophilia
Pregnancy:No evidence of increased birth defects. Evidence shows that Kaletra is safe in the short-term for mothers and infants.
Women-Specific Information:Because Kaletra reduces the levels of some hormonal contraceptives, talk to your health care provider about changing to or adding other methods of contraception if you take Kaletra
Who Produces the Drug:Abbott
Web Site for Drug Info: Kaletra
Patient Assistance: Kaletra Patient Assistance
1-800-222-6885
Abbott Patient Assistance Program
Co-payment assistance -- speak to your health care provider about obtaining an Abbott Positive Partnership PLUS Card or call 1-888-458-6442

Lexiva

Brand Name: Lexiva (Telzir in some countries outside the US)
Other Name(s):FPV
Generic Name(s):Fosamprenavir
Class of Drug:PI
Common Side Effects:Nausea, vomiting, diarrhea, stomach pain, gas, headaches, rash, numbness or tingling around the mouth
Serious Side Effects:Kidney stones (drink 8 glasses of water daily to lower risk of kidney stones), lipodystrophy, increased cholesterol and triglycerides, liver problems, sulfa allergy, Stevens-Johnson syndrome (severe skin rash accompanied by fever, fatigue, muscle or joint aches, blisters, facial and tongue swelling), increased bleeding in people with hemophilia, high blood sugar, hemolytic Anemia (destruction of red blood cells)
Special Considerations:Triglyceride and cholesterol levels should be checked before starting Lexiva and regularly during treatment. It may be necessary for your health care provider to treat high cholesterol and triglycerides with other medications.
Pregnancy:No information in human pregnancy
Women-Specific Information:Because Lexiva reduces the levels of some hormonal contraceptives, talk to your health care provider about changing to or adding other methods of contraception if you take Lexiva
Who Produces the Drug:Viiv Healthcare
Web Site for Drug Info:www.lexiva.com
Patient Assistance:Lexiva Patient Assistance
Co-payment assistance at www.mysupportcard.com/
1-866-728-4368

Norvir

Brand Name: Norvir
Other Name(s):RTV
Generic Name(s):Ritonavir
Class of Drug:PI
Common Side Effects:Nausea, diarrhea, stomach pain, loss of appetite, headaches, heartburn, fatigue, weakness, dizziness, trouble sleeping, numbness and tingling around the mouth, changes in taste
Serious Side Effects:Liver problems, pancreatitis, lipodystrophy, increased cholesterol and triglycerides, high blood sugar, increased bleeding in people with hemophilia, increased risk of developing abnormal heart rhythms
Special Considerations:Norvir is most commonly used to boost other drugs. Taking Norvir with certain allergy medications, sedatives, heart medications, and migraine medications can increase the risk of their side effects.
Pregnancy:No evidence of increased likelihood of birth defects; use only to boost other HIV drugs
Women-Specific Information:Some research suggests that women may be more likely than men to experience side effects when taking Norvir, especially nausea, vomiting, aches and fatigue, and numbness and tingling around the mouth
Who Produces the Drug:Abbott
Web Site for Drug Info: Norvir
Patient Assistance: Norvir Patient Assistance Program
1-800-222-6885
Co-payment assistance program at 800-441-4987


Prezista

Brand Name: Prezista
Other Name(s):DRV
Generic Name(s):Darunavir
Class of Drug:PI
Common Side Effects:Nausea, vomiting, diarrhea, constipation, headaches, rash
Serious Side Effects:Liver problems, lipodystrophy, increased cholesterol and triglycerides, sulfa allergy, high blood sugar, increased bleeding in people with hemophilia, Stevens-Johnson syndrome (severe skin rash accompanied by fever, fatigue, muscle or joint aches, blisters, facial and tongue swelling)
Special Considerations:Liver function should be tested before starting Prezista. Increased liver function monitoring is a good idea for people with hepatitis or other liver problems. Prezista is not recommended for people with severe liver damage.
Pregnancy:No information in human pregnancy
Women-Specific Information:Because Prezista reduces the levels of some hormonal contraceptives, talk to your health care provider about changing to or adding other methods of contraception if you take Prezista
Who Produces the Drug:Janssen (formerly Tibotec)
Web Site for Drug Info:www.prezista.com
Patient Assistance: Prezista Patient Assistance Program
866-836-0114
Tibotec copay assistance: 866-961-7169


Reyataz

Brand Name: Reyataz
Other Name(s):ATV
Generic Name(s):Atazanavir
Class of Drug:PI
Common Side Effects:Nausea, vomiting, diarrhea, stomach pain, headaches, rash, jaundice (yellowing of skin and eyes), trouble sleeping, depression, dizziness, muscle aches, fever
Serious Side Effects:Liver problems, lipodystrophy, increased cholesterol and triglycerides, changes in heart rhythm, peripheral neuropathy, kidney stones, increased bleeding in people with hemophilia, gallbladder problems, Stevens-Johnson syndrome (severe skin rash accompanied by fever, fatigue, muscle or joint aches, blisters, facial and tongue swelling)
Pregnancy:No evidence of increased birth defects. There is some concern about Reyataz's effect on infant liver health.
Women-Specific Information:Because Reyataz reduces the levels of some hormonal contraceptives, talk to your health care provider about the right birth control pill for you
Who Produces the Drug:Bristol-Myers Squibb
Web Site for Drug Info:www.reyataz.com
Patient Assistance:Patient assistance or 888-281-8981
Co-payment assistance


Viracept

Brand Name: Viracept
Other Name(s):NFV
Generic Name(s):Nelfinavir
Class of Drug:PI
Common Side Effects:Nausea, diarrhea, gas, rash
Serious Side Effects:Liver problems, lipodystrophy, increased cholesterol and triglycerides, high blood sugar, increased bleeding in people with hemophilia
Pregnancy:No evidence of increased birth defects. Evidence shows that Viracept is safe in the short-term for mothers and infants.
Women-Specific Information:Because Viracept reduces the levels of some hormonal contraceptives, talk to your health care provider about changing to or adding other methods of contraception if you take Viracept. Research suggests that women taking Viracept are less likely than men to experience diarrhea, but more likely to experience stomach pain, itching, or rash.
Who Produces the Drug:Viiv Healthcare
Web Site for Drug Info: Viracept
Patient Assistance:Viracept patient assistance program or
877-784-4842
Co-payment assistance


Entry and Fusion Inhibitors

Fusion Inhibitors

Fuzeon

Brand Name: Fuzeon
Other Name(s):T-20
Generic Name(s):Enfuvirtide
Class of Drug:Fusion Inhibitor
Common Side Effects:Skin reactions at site of shots (including pain and discomfort, redness, bumps, itching, swelling, and hardened skin), trouble sleeping, headaches, loss of appetite, depression, fatigue, muscle pain, constipation
Serious Side Effects:Increased risk for bacterial pneumonia, peripheral neuropathy, pancreas problems, possible rare allergic reaction (including rash, fever, nausea and vomiting, chills, shaking, low blood pressure, and increased liver enzymes)
Pregnancy:No information in human pregnancy
Who Produces the Drug:Trimeris/Roche; sold by Genentech
Web Site for Drug Info:www.fuzeon.com
Patient Assistance:Fuzeon patient assistance
1-877-438-9366
No co-payment assistance available


Entry Inhibitors

Selzentry

Brand Name: Selzentry (Celsentri outside the US)
Other Name(s):MVC
Generic Name(s):Maraviroc
Class of Drug:Entry Inhibitor
Common Side Effects:Cough, fever, colds, rash, muscle and joint pain, stomach pain, dizziness
Serious Side Effects:Liver problems, cardiovascular problems, feeling dizzy or blacking out when standing
Special Considerations:A laboratory test called a "tropism" test is needed before Selzentry is used to determine if treatment with the drug will be useful
Pregnancy:No information in human pregnancy
Women-Specific Information:Selzentry is safe to use while using birth control pills
Who Produces the Drug:Viiv Healthcare
Web Site for Drug Info:www.selzentry.com
Patient Assistance:Viiv patient assistance program or 1-877-784-4842
Co-payment assistance
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This article was provided by The Well Project. Visit The Well Project's Web site to learn more about their resources and initiatives for women living with HIV. The Well Project shares its content with TheBody.com to ensure all people have access to the highest quality treatment information available. The Well Project receives no advertising revenue from TheBody.com or the advertisers on this site. No advertiser on this site has any editorial input into The Well Project's content.
 
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HIV Medications: When to Start and What to Take -- A Guide From TheBody.com
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