Print this page    •   Back to Web version of article

Medical News
Experimental Genital Herpes Vaccine Fails Major Clinical Trial

October 1, 2010

Researchers said on Thursday that an experimental vaccine to protect women from genital herpes disease had failed in a Phase III trial. GlaxoSmithKline, which manufactured the candidate, said it is abandoning its work on the Simplirix vaccine. The Herpevac trial, which began in 2002, enrolled 8,323 women ages 18-30 at 50 sites in the United States and Canada. All were free of herpes simplex virus types 1 and 2 at enrollment. Half the women received the Havrix hepatitis A vaccine (control group), while the others received Simplirix, which contains HSV protein and an adjuvant to boost immune response (intervention group). Volunteers were vaccinated at baseline and months one and six, then followed up for 20 months. The results found the vaccine candidate was ineffective. Its estimated efficacy was 20 percent, a level that is not statistically significant from zero. Researchers are continuing to evaluate the data, but it is not known now why the vaccine failed. Participants who received Simplirix will be offered the opportunity to receive Havrix. The National Institute of Allergy and Infectious Diseases supported the study. For more information, visit www.niaid.nih.gov/news/newsreleases/2010/Pages/Herpevac.aspx and www.niaid.nih.gov/news/QA/Pages/HerpevacQA.aspx.

Back to other news for October 2010

Excerpted from:
Los Angeles Times
09.30.2010; Thomas H. Maugh II




This article was provided by CDC National Prevention Information Network. It is a part of the publication CDC HIV/Hepatitis/STD/TB Prevention News Update. You can find this article online by typing this address into your Web browser:
http://www.thebody.com/content/art58736.html

General Disclaimer: TheBody.com is designed for educational purposes only and is not engaged in rendering medical advice or professional services. The information provided through TheBody.com should not be used for diagnosing or treating a health problem or a disease. It is not a substitute for professional care. If you have or suspect you may have a health problem, consult your health care provider.