The Body: The Complete HIV/AIDS Resource
Follow Us Follow Us on Facebook Follow Us on Twitter Download Our App 
Professionals >> Visit The Body PROThe Body en Espanol
  • Email Email
  • Comments Comments
  • Printable Single-Page Print-Friendly
  • Glossary Glossary

Medical News

Spectrum of Cancer Risk Late After AIDS Onset in the United States

September 17, 2010

"Persons living with AIDS today remain at elevated cancer risk. Highly active antiretroviral therapy (HAART), widely available since 1996, prolongs life, but immune function is not fully restored," noted the study authors, who assessed long-term cancer risk among persons with AIDS relative to the general population and the impact of HAART on cancer incidence.


The records of 263,254 adults and adolescents with AIDS (1980-2004) living in 15 US regions were matched to cancer registries to capture incident cancers during years three through five and six through 10 following AIDS onset. Risks relative to the general population were assessed using standardized incidence ratios (SIRs). Rate ratios (RRs) were employed to compare cancer incidence before and after 1996 to assess the impact of HAART availability.

Risk was elevated for the two main AIDS-defining cancers: Kaposi sarcoma (SIRs, 5,321 and 1,347 in years three through five and six through 10, respectively) and non-Hodgkin lymphoma (SIRs, 32 and 15). Incidence of both cancers declined in the HAART era (1996-2006). Risk was elevated for all non-AIDS-defining cancers combined (SIRs, 1.7 and 1.6 in years three through five and six through 10, respectively), and for the following specific non-AIDS-defining cancers: Hodgkin lymphoma and cancers of the oral cavity and/or pharynx, tongue, anus, liver, larynx, lung and/or bronchus, and penis. Anal cancer incidence increased between 1990-1995 and 1996-2006 (RR, 2.9; 95 percent confidence interval [CI], 2.1-4.0), as did incidence of Hodgkin lymphoma (RR, 2.0; 95 percent CI, 1.3-2.9).

"Among people who survived for several years or more after an AIDS diagnosis, we observed high risks of AIDS-defining cancers and increasing incidence of anal cancer and Hodgkin lymphoma," the authors concluded.

Back to other news for September 2010

Adapted from:
Archives of Internal Medicine
08.09.2010; Vol. 170; No. 15: P. 1337-1345, Edgar P. Simard, PhD, MPH; Ruth M. Pfeiffer, PhD; Eric A. Engels, MD, MPH

  • Email Email
  • Comments Comments
  • Printable Single-Page Print-Friendly
  • Glossary Glossary

This article was provided by CDC National Prevention Information Network. It is a part of the publication CDC HIV/Hepatitis/STD/TB Prevention News Update.
See Also
Fact Sheet on HIV/AIDS Malignancies
More HIV/AIDS-Related Cancer Research

No comments have been made.

Add Your Comment:
(Please note: Your name and comment will be public, and may even show up in
Internet search results. Be careful when providing personal information! Before
adding your comment, please read's Comment Policy.)

Your Name:

Your Location:

(ex: San Francisco, CA)

Your Comment:

Characters remaining: