Oral Candidiasis (Thrush)
The benefits of preventive antifungal therapy are unclear. This is partly because of the risk it poses in the development of drug resistance, drug interactions and drug side effects. In general, long-term use of anti-fungals should be reserved for people with frequent or severe recurrences of candidiasis, particularly as the CD4+ cell count decline. People who experience occasional or infrequent recurrences of oral candidiasis (no more than three episodes per year) can be treated for each episode.
If recurrences are more frequent or severe, or if there is a history of esophageal candidiasis, preventative therapy with fluconazole may be recommended. According to the need, daily, three times weekly, or weekly fluconazole at a dose of 100-200mg is recommended. Again, the potential risk of developing azole resistance must be taken into account when considering long term use of systemic therapy for preventative purposes.
This article was provided by Project Inform. Visit Project Inform's website to find out more about their activities, publications and services.