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Oral Candidiasis (Thrush)

November 2005

Side Effects and Drug Interactions

Common side effects of oral azole drugs (ketoconazole, fluconazole and itraconazole) are nausea, vomiting and belly pain. Others include headaches, dizziness, drowsiness, fever, diarrhea, rash and changes in the sense of taste. The most serious problem is liver toxicity, but this is rare and usually reverses after treatment when the drug is stopped. Nevertheless, liver function should be monitored closely, particularly with ketoconazole.

Intravenous amphotericin B may pose serious side effects, including kidney toxicity. The most common side effects are fever, shaking, chills, altered blood pressure, nausea, vomiting and headache. These reactions are usually severe after the first few doses and lessen with subsequent treatment. Liposomal versions of the drug (like Abelcet) are generally less toxic and as effective than its earlier formula. Intravenous amphotericin B should only be used in cases where there is a direct threat to life or all other treatments have failed.

Oral azole drugs have similar drug interactions:

Amphotericin B has several drug interactions:

Other drug interactions may occur. More details can be found in Project Inform's Drug Interactions Chart and from your pharmacist.

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