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Oral Candidiasis (Thrush)

November 2005

Treating Oral Candidiasis

Drug Name Dose Side Effects Notes
Topical Therapies
Clotrimazole
(Mycelex) trouches
10mg 4-5 times daily for 1-2 weeks May cause altered taste and stomach upset Suck slowly; do not chew or swallow whole
Nystatin
(Mycostatin) Pastille
1-2 pastilles
4-5 times daily
May cause irritation in the mouth; nausea Suck slowly; do not chew or swallow whole
Nystatin
(Mycostatin) oral suspension
5ml four times daily for 7-14 days May cause stomach upset Swish around mouth before swallowing
Systemic Therapies
Ketoconazole
(Nizoral) tablet
200mg a day, 7-14 days;
400mg day, 14-21 days*
Nausea, vomiting, stomach pain; liver toxicity Monitor liver function while taking this drug; take with food
Itraconazole
(Sporanox)
100mg a day, 7-14 days;
200mg a day, 14-21 days*
Nausea, vomiting, stomach pain; liver toxicity Monitor liver function while taking this drug
Fluconazole
(Diflucan)
200mg a day, 7-14 days;
200mg a day, 14-21 days*
Nausea, vomiting, stomach pain; liver toxicity Monitor liver function while taking this drug
Amphotericin B (Fungizone)
Amphotericin B lipid complex (Abelcet)
100mg a day four times daily (oral suspension);
0.5mg/kg a day, 14-21 days (intravenous)*
For intravenous form: kidney toxicity, electrolyte losses, fever, chills, sweats For oral suspension, swish around mouth before swallowing; monitor kidney function
Others
Gentian violet
(1% solution in water)
Applied to affected areas twice a day for three days May cause swelling Available over-the-counter; may be useful for recurrent infections when applied every 7 days for 1 month; messy application

* Esophageal Candidiasis


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