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TMC278 (Rilpivirine) Stands Up to Efavirenz in Battle of First-Line NNRTIs; FDA Approval May Be Drawing Near

By Myles Helfand

July 28, 2010

Myles is the editorial director of and

The NNRTI efavirenz (EFV, Sustiva, Stocrin) is one of the most popular first-line HIV medications, but its risk of associated neurological side effects sometimes leaves people seeking other options. An NNRTI in late-stage development, TMC278 (rilpivirine), appears firmly set on offering treatment-naive people a viable alternative.

It's too soon to predict whether TMC278 will succeed in that goal. But research presented at AIDS 2010 appears to support this young upstart's progress toward U.S. Food and Drug Administration (FDA) approval, perhaps within the next several months.

The Gist

For a more detailed breakdown of the ECHO and THRIVE 48-week results, take a look at the abstract of the AIDS 2010 presentation by Cal Cohen, M.D., or read Mark Mascolini's lovely recap of the study details at We also hope to add the slides from Cohen's presentation to this page soon.

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