Antiretroviral Treatment of Adult HIV Infection: 2010 Recommendations of the International AIDS Society-USA Panel
July 27, 2010
"Successful antiretroviral therapy (ART) is associated with dramatic decreases in AIDS-defining conditions and their associated mortality," the authors wrote in introducing their updated treatment recommendations.
"Patient readiness for treatment should be confirmed before initiation of antiretroviral treatment," the panel said. "Therapy is recommended for asymptomatic patients with a CD4 cell count less than or equal to 500/microliter, for all symptomatic patients, and those with specific conditions and comorbidities. Therapy should be considered for asymptomatic patients with CD4 cell count above 500/microliter.
"Components of the initial and subsequent regimens must be individualized, particularly in the context of concurrent conditions," wrote the authors, who presented these considerations in an accompanying table. "Patients receiving antiretroviral treatment should be monitored regularly; treatment failure should be detected and managed early, with the goal of therapy, even in heavily pretreated patients, being HIV-1 RNA suppression below commercially available assay quantification limits," the panel advised.
The full recommendations are available online via open access; visit http://jama.ama-assn.org/cgi/content/full/304/3/321.
Journal of the American Medical Association
07.21.2010; Vol. 304; No. 3: P. 321-333; Melanie A. Thompson, MD; Judith A. Aberg, MD; Pedro Cahn, MD; Julio S.G. Montaner, MD; Guiliano Rizzardini, MD; Amalio Telenti, MD, PhD; José M. Gatell, MD, PhD; Huldrych F. Günthard, MD; Scott M. Hammer, MD; Martin S. Hirsch, MD; Donna M. Jacobsen, BS; Peter Reiss, MD, PhD; Douglas D. Richman, MD; Paul A. Volberding, MD; Patrick Yeni, MD; Robert T. Schooley, MD
DHHS Adult and Adolescent Antiretroviral Treatment Guidelines Panel Releases Supplemental Information Regarding the Role of Rilpivirine as Initial Therapy
Guidelines for Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents
This article was provided by CDC National Prevention Information Network. It is a part of the publication CDC HIV/Hepatitis/STD/TB Prevention News Update.
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