Selzentry Labeling Includes New Warnings for People With Kidney Problems
By Myles Helfand
June 2, 2010
The CCR5 inhibitor Selzentry (Celsentri, maraviroc) should be used with caution by HIV-positive people with kidney problems, according to a U.S. Food and Drug Administration release. The release provides details on several changes that have just been made to the official drug labeling for Selzentry, all of which have to do with the renal (kidney) issues.
This is all pretty new information. Although it was previously known that some Selzentry dose adjustments were likely needed for people with kidney failure, that's also true of an awful lot of drugs, since the kidneys basically act as the body's filtration system -- and if they stop working, it seriously hurts the body's ability to prevent drug levels from building up dangerously.
The new Selzentry labeling will include a number of specific warnings and other information related to the kidneys, including:
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