May 10, 2010
Melbourne, Australia -- The Board of Avexa Limited (ASX:AVX) has resolved to cease any further development of its lead HIV program, ATC, following the unsuccessful conclusion of partnering discussions with global pharmaceutical companies.
This announcement follows the 2 October 2009 closure of ATC's Phase III clinical trial. Since then, detailed results from this study at 24 weeks were provided to interested parties as part of a formal process designed to secure a licensing transaction. On Thursday, 6 May 2010, the last party involved in this process notified Avexa that it did not intend to submit a term sheet. Consequently, the Board of Avexa has resolved to cease all activities for this program. Avexa has commenced a strategic review of its remaining programs and intends to consider suitable merger, acquisition, in-licensing opportunities and other corporate initiatives.
The Company has taken immediate action to reduce costs and will continue to actively preserve capital, including taking further action to significantly reduce overhead in combination with the strategic review process. Additionally, Julian Chick has resigned from the Board, effective immediately, and will leave his position as the Chief Executive Officer on 31 May, 2010.
"The Board wishes to extend its appreciation to Julian for his tireless efforts to create shareholder value via the development of ATC. The asset's clinical milestone timelines were consistently achieved and the trial results, both in terms of safety and efficacy, were excellent. Unfortunately, for ATC, the compound's successful development did not translate into a commercial deal to partner the program with a global pharma company and, as a result, the program is no longer viable. We are grateful for Julian's contributions to the company as CEO since the company's inception." said Nathan Drona, Avexa's Chairman.
The Board is of the view that Avexa has exhausted all possible avenues to complete a global licensing transaction for ATC. However, it intends to continue discussions with smaller regionally focused companies who have expressed an interest in a regional licensing transaction for ATC. The probability of this type of transaction being executed remains uncertain and if completed would be unlikely to generate a meaningful return on the capital invested in the ATC program to date.
Over the past two years, Avexa has been in active discussions with potential partners. However, in early March 2010, the company initiated the final stage of the partnering process via a full review of the data set from the Phase III study, which incorporated a detailed presentation of the results by Avexa scientists. The primary objective of the process was to secure a license agreement for ATC with one of several global pharmaceutical companies who had previously been in a dialogue with the Company. Unfortunately, this partnering process did not result in a partner for ATC.
Some of the key reasons why potential partners involved did not proceed to the term sheet stage included:
Accordingly, the Board of Avexa wishes to advise shareholders that:
In the interim, the Company will be actively preserving capital and taking further action to significantly reduce overhead in combination with the strategic review process. Avexa had a net cash position of approximately $26.6m as at 31 March 2010 and expects to have approximately $23m in net cash as at 30 June 2010 after allowing for net current liabilities and expected redundancy and restructuring costs.
"The Board and Senior Management of Avexa have worked diligently over the past two years with the explicit objective of securing a global licensing deal with a global pharmaceutical company for ATC. We are extremely disappointed that this key objective was not achieved. Our top priority moving forward is to preserve capital while completing our strategic review with the primary focus of uncovering a transaction that will be value accretive for our shareholders. We look forward to updating the market in the near-term with our progress" continued Nathan Drona, Chairman of Avexa.