|Median PSA level (HIV-)||Median PSA level (HIV+)||p-value*|
|0.71 (n*=48)||0.54 (n=52)||0.03|
|0.96 (n=87)||0.68 (n=76)||0.0002|
|1.5 (n=44)||1.33 (n=24)||0.66|
|n = the number of men included in the age range and HIV grouping.|
p-value = the statistical power of the difference between the two groups. At a minimum, an observation needs to have a power of .05 to be considered meaningful and significant. The smaller the p-value, the more statically important or significant the observation. Thus a p-value of .0002 is considered very powerful.
This study is important as it is estimated that about 14 percent of HIV-positive African American men are over the age of forty and should be undergoing age-appropriate screening for prostate cancer. Doctors should be aware that African American men living with HIV may have lower PSA levels compared to their HIV-negative counterparts and be aware that this may make early detection of prostate cancer by relying on PSA more difficult. It is likely that this information also applies to men of different races and ethnicities.