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Atazanavir and Side Effects

July 2004

A note from TheBody.com: Since this article was written, the HIV pandemic has changed, as has our understanding of HIV/AIDS and its treatment. As a result, parts of this article may be outdated. Please keep this in mind, and be sure to visit other parts of our site for more recent information!

Results from two studies confirm the benefits of the protease inhibitor atazanavir (Reyataz) with regard to side effects. Several studies show that other protease inhibitors can reduce insulin sensitivity in the body. Reduced insulin sensitivity can lead to diabetes. A study reported at the 11th Conference on Retroviruses and Opportunistic Infections (CROI) found that atazanavir had no effect on insulin sensitivity.

A second study reported at CROI found that Kaletra had more negative effects on cholesterol and triglycerides than atazanavir + ritonavir. People entering the study had elevated triglycerides and cholesterol from previous regimens. Those receiving atazanavir had reductions in both total cholesterol and triglycerides over 48 weeks. Total cholesterol dropped by 8% and fasting triglycerides dropped by 4%. In contrast, participants taking Kaletra had a 6% increase in total cholesterol and a 30% increase in fasting triglycerides.

This is not to suggest that atazanavir has a lipid (fat)-lowering effect. Rather, an increasing number of studies have found that it simply does not have the negative effects on lipids that other drugs do. Though both studies presented here were rather small, they certainly suggest that atazanavir may be a reasonable alternative for people who have experienced lipid and insulin problems from other anti-HIV drugs.


Back to the Project Inform Perspective July 2004 contents page.

A note from TheBody.com: Since this article was written, the HIV pandemic has changed, as has our understanding of HIV/AIDS and its treatment. As a result, parts of this article may be outdated. Please keep this in mind, and be sure to visit other parts of our site for more recent information!



  
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This article was provided by Project Inform. It is a part of the publication Project Inform Perspective. Visit Project Inform's website to find out more about their activities, publications and services.
 
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More News and Research on Atazanavir (Reyataz)

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