Safety Risk Associated With HIV Drug Videx
February 2, 2010
A rare but serious liver disorder has been reported in some patients taking the HIV drug Videx (didanosine) and its delayed-release formulation, Videx EC, the Food and Drug Administration (FDA) said Monday.
FDA said 42 cases of non-cirrhotic portal hypertension have been reported in patients taking Videx/Videx EC during an 18-year period. "Non-cirrhotic portal hypertension occurs when blood flow in the portal vein, a major vein in the liver, slows down and leads to severely enlarged veins in the esophagus. These enlarged veins, called esophageal varices, are thin and can break open, resulting in serious, and potentially fatal, bleeding," FDA said. The condition has led to the death of four patients.
United Press International
This article was provided by U.S. Centers for Disease Control and Prevention. It is a part of the publication CDC HIV/Hepatitis/STD/TB Prevention News Update. Visit the CDC's website to find out more about their activities, publications and services.