Acyclovir and Transmission of HIV-1 From Persons Infected With HIV-1 and HSV-2
January 25, 2010
"Most persons who are infected with [HIV-1] are also infected with herpes simplex virus type 2 (HSV-2), which is frequently reactivated and is associated with increased plasma and genital levels of HIV-1," wrote the authors. "Therapy to suppress HSV-2 reduces the frequency of reactivation of HSV-2 as well as HIV-1 levels, suggesting that suppression of HSV-2 may reduce the risk of transmission of HIV-1."
At 14 sites in Africa, the researchers enrolled 3,408 couples in which one partner was infected with both HIV-1 and HSV-2 and was not taking antiretroviral therapy at time of enrollment. HIV-positive partners were randomized to receive either a placebo or acyclovir (400mg orally, twice daily). At all visits, participants were given intensive counseling about risk reduction, condoms, and treatment for STDs according to World Health Organization guidelines.
New England Journal of Medicine
01.20.2010; doi10.1056/NEJMoa0904849; C. Celum and others
This article was provided by U.S. Centers for Disease Control and Prevention. It is a part of the publication CDC HIV/Hepatitis/STD/TB Prevention News Update. Visit the CDC's website to find out more about their activities, publications and services.