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New Dosing Recommendations Retrovir (Zidovudine) Syrup for HIV-Infected Infants

November 6, 2009

On November 6, 2009, the Food and Drug Administration (FDA) approved revised pediatric dosing recommendations that expand dosing to include children starting treatment at four weeks of age.

The revised label contains the following recommendation:

The recommended dosage in pediatric patients 4 weeks of age and older and weighing >4 kg is provided in Table 1. RETROVIR Syrup should be used to provide accurate dosage when whole tablets or capsules are not appropriate.

Table 1: Recommended Pediatric Dosage of RETROVIR

Body Weight (kg)
Total Daily Dose
Dosage Regimen and Dose
b.i.d.
t.i.d
4 to < 9
24 mg/kg/day
12 mg/kg
8 mg/kg
> 9 to < 30
18 mg/kg/day
9 mg/kg
6 mg/kg
> 30
600 mg/day
300 mg
200 mg


  
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This article was provided by U.S. Food and Drug Administration. Visit the FDA's website to find out more about their activities and publications.
 
See Also
More on HIV Medications
More News on AZT (Zidovudine, Retrovir)
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