Effect of Early Versus Deferred Antiretroviral Therapy for HIV on Survival
April 9, 2009
"The optimal time for the initiation of antiretroviral therapy for asymptomatic patients with [HIV] is uncertain," the authors wrote in introducing the current study.
The second analysis involved 9,155 patients: 2,220 (24 percent) initiated therapy at a CD4+ count of more than 500, and 6,935 (76 percent) deferred therapy. Among patients in the deferred therapy group, there was a 94 percent increase in the risk of death (relative risk, 1.94; 95 percent CI, 1.37 to 2.79; P<0.001).
"The early initiation of antiretroviral therapy before the CD4+ count fell below two prespecified thresholds significantly improved survival, as compared with deferred therapy," the authors concluded.
New England Journal of Medicine
04.01.2009; doi: 10.1056/NEJMoa0807252; Mari M. Kitahata, M.D., M.P.H., and others
This article was provided by CDC National Prevention Information Network. It is a part of the publication CDC HIV/Hepatitis/STD/TB Prevention News Update.