Print this page    •   Back to Web version of article

Medical News
CD4 Counts Decline Despite Nutritional Recovery in HIV-Infected Zambian Children With Severe Malnutrition

February 13, 2009

The researchers undertook the current study to establish the contribution that severe malnutrition makes to CD4 lymphopenia in HIV-infected and -uninfected children and to determine the changes in CD4 count during nutritional rehabilitation.

From a pediatric ward in Lusaka, 56 children with severe malnutrition and with or without HIV infection were recruited for measurement of CD4 counts on admission, on discharge, and at final nutritional recovery.

The children with severe malnutrition but without HIV were found to have normal CD4 counts. CD4 counts in HIV-infected children with severe malnutrition were reduced, more so in those without edema compared to those with edema. The mean CD4 count of HIV-infected severely malnourished children fell despite nutritional recovery. At the time of full nutritional recovery, more than 85 percent of the children with HIV required antiretroviral therapy.

"Severe malnutrition did not reduce the CD4 counts of children without HIV," the authors concluded. "HIV-infected children with severe malnutrition may respond well to nutritional rehabilitation, despite low CD4 counts, but nearly all require early antiretroviral therapy to prevent disease progression."

Back to other news for February 2009

Excerpted from:
Pediatrics
02.2009; Vol. 123; No. 2: P. e347-e351; Stephen Miles Hughes, B.Sc., M.B.Ch.B.; Beatrice Amadi, M.D., M.Med.; Mwiya Mwiya, B.Sc., M.B.Ch.B., M.Med.; Hope Nkamba, B.Sc.; Georgina Mulundu, M.Sc.; Andrew Tomkins, F.Med.Sci.; David Goldblatt, M.D., Ph.D.




This article was provided by CDC National Prevention Information Network. It is a part of the publication CDC HIV/Hepatitis/STD/TB Prevention News Update. You can find this article online by typing this address into your Web browser:
http://www.thebody.com/content/art50552.html

General Disclaimer: TheBody.com is designed for educational purposes only and is not engaged in rendering medical advice or professional services. The information provided through TheBody.com should not be used for diagnosing or treating a health problem or a disease. It is not a substitute for professional care. If you have or suspect you may have a health problem, consult your health care provider.