| Efavirenz (Sustiva) plus ... |
| Amprenavir |
Decreases amprenavir level by 36% and increases efavirenz level by 15% in blood. Amprenavir dose may need to be increased. |
| Atazanavir |
Decreases atazanavir level in blood. Atazanavir should be boosted with ritonavir if used with efavirenz. |
| Atorvastatin |
Decreases atorvastatin level in blood. Atorvastatin dose may need to be increased. |
| Clarithromycin |
Slightly increases efavirenz level but decreases clarithromycin level by 39% (increases 14-hydroxy clarithromycin level by 34%) in blood. No dose adjustment currently recommended. |
| Fluconazole |
Increases efavirenz level by 16% in blood. No dose adjustment currently recommended. |
| Food |
Should be taken on an empty stomach. Increases efavirenz level 10–50% in blood. |
| Fosamprenavir |
May significantly decrease fosamprenavir level in blood. Use only boosted fosamprenavir at 1,400 mg + 300 mg ritonavir once a day. |
| Indinavir |
Decreases indinavir level by 31% in blood. Indinavir dose should be increased to 1,000 mg 3 times a day or 800 mg twice daily if boosted with ritonavir. |
| Kaletra |
Decreases lopinavir level by about 25% (trough by about 33%). Kaletra dose should be increased to 4 capsules twice a day. |
| Methadone |
Decreases methadone level by 52% in blood. Check for methadone withdrawal symptoms and adjust methadone dose accordingly. |
| Nelfinavir |
Increases nelfinavir level by 20% and decreases efavirenz level by 22% in blood. No dose adjustments currently recommended. |
| Nevirapine |
Decreases efavirenz level by 22% in blood. Efavirenz dose may need to be increased to 800 mg once a day. |
| Rifabutin |
Decreases rifabutin level in blood. Increase rifabutin dose by 50% if taken daily or double the dose if taken 3 times a week. |
| Rifampin |
Decreases efavirenz level by 26% in blood. Impact of interaction is uncertain. |
| Ritonavir |
Should be used together with caution. Increases efavirenz level by 21% and ritonavir level by 18% in blood. Check for side effects. |
| Saquinavir (Fortovase) |
Decreases efavirenz level by 12% and decreases saquinavir level by 62% in blood. Requires ritonavir boosting. |
| St. John's Wort |
Should be used together with great caution. May decrease efavirenz level in blood. |
| Simvastatin |
Decreases simvastatin level in blood. Simvastatin dose may need to be increased. |
| Voriconazole |
Should not be used together. Increases risk of side effects. |
| Ethinyl estradiol (Ortho-Novum) plus ... |
| Amprenavir |
Should not be used together. May decrease ethinyl estradiol and norethindrone levels in blood. Use another form of contraception. |
| Atazanavir |
Should be used together with caution. Increases ethinyl estradiol level in blood. Use lowest effective dose of ethinyl estradiol. |
| Delavirdine |
May increase ethinyl estradiol level in blood. Impact of interaction is uncertain. |
| Fluconazole |
Increases ethinyl estradiol level by up to 38% in blood. No dose adjustments currently recommended. |
| Indinavir |
Should be used together with caution. Increases ethinyl estradiol level by 24% in blood. |
| Kaletra |
Should not be used together. Decreases ethinyl estradiol level by 42% in blood. Use another form of contraception. |
| Nelfinavir |
Should not be used together. Decreases ethinyl estradiol level by 47% in blood. Use another form of contraception. |
| Nevirapine |
Should not be used together. Decreases ethinyl estradiol level in blood. Use another form of contraception. |
| Rifabutin |
Should not be used together. May decrease ethinyl estradiol level in blood. Use another form of contraception. |
| Rifampin |
Should not be used together. May decrease ethinyl estradiol level in blood. Use another form of contraception. |
| Ritonavir |
Should not be used together. Decreases ethinyl estradiol level by 40% in blood. Use an another form of contraception. |
| Fluconazole (Diflucan) plus ... |
| Amphotericin B |
May interfere with the activity of amphotericin B. |
| Astemizole |
Should not be used together*. Increases risk of side effects. |
| AZT |
Increases AZT level by 74% and may increase fluconazole level in blood. Check for toxicity. |
| Benzodiazepines |
May increase benzodiazepine level in blood. |
| Cimetidine |
Decreases fluconazole level by 13% in blood. No dose adjustment recommended. |
| Cisapride |
Should not be used together*. Increases risk of side effects. |
| Cyclosporine |
Should be used together with caution. Increases cyclosporine level by 92% in blood. Check cyclosporine level and serum creatinine. |
| Efavirenz |
Increases efavirenz level by 16% in blood. No dose adjustment currently recommended. |
| Ethinyl estradiol |
Increases ethinyl estradiol level by up to 38% in blood. No dose adjustments currently recommended. |
| Glipizide |
Should be used together with caution. Increases glipizide level by 49% in blood. Closely check blood sugar for hypoglycemia. |
| Glyburide |
Should be used together with caution. Increases glyburide level by 44% in blood. Closely check blood sugar for hypoglycemia. |
| Hydrochlorothiazide |
Increases fluconazole level by 45% in blood. |
| Indinavir |
Decreases indinavir level by 19% in blood. |
| Levonorgestrel |
Increases levonorgestrel level by 25% in blood. |
| Loratadine |
May affect loratadine and/or fluconazole level in blood. |
| Phenytoin |
Increases phenytoin level by 88% in blood. |
| Ranitidine |
May decrease fluconazole level in blood. |
| Rifabutin |
Should be used together with caution. May increase rifabutin level by up to 80% in blood. Increases risk of painful eye inflammation. |
| Rifampin |
Should be used together with caution. Decreases fluconazole level by 23% in blood. May require higher dose of fluconazole. |
| Ritonavir |
Increases ritonavir level by 12% in blood. No dose adjustment recommended; however, check for liver toxicity. |
| Saquinavir (Fortovase) |
May increase saquinavir level in blood. However, no dose adjustment recommended. |
| Saquinavir (Invirase) |
May increase saquinavir level in blood. However, no dose adjustment recommended. |
| Tacrolimus |
Should be used together with caution. May increase tacrolimus level in blood and increases risk of kidney toxicity. |
| Theophylline |
Should be used together with caution. Increases theophylline level by 21% in blood. Check theophylline level. |
| Tolbutamide |
Should be used together with caution. Increases tolbutamide level by 26% in blood. Closely check blood sugar for hypoglycemia. |
| Trimetrexate |
May affect trimetrexate and/or fluconazole level in blood. |
| Warfarin |
Should be used together with caution. Check for increases in prothrombin (coagulation) time. |
| Fosamprenavir (Lexiva) plus ... |
| Alprazolam |
Should be used together with caution. May require decrease in alprazolam dose. |
| Amiodarone |
Should be used together with great caution. May increase serious side effects. Check amiodarone blood concentrations if possible. |
| Atorvastatin |
Fosamprenavir alone and with ritonavir increases atorvastatin level in blood. Lower atorvastatin dose to no more than 20 mg/day or use alternatives. |
| Bepridil |
Should be used together with great caution. Increases risk of serious side effects. |
| Calcium channel blockers |
Should be used together with great caution. Check for side effects. |
| Carbamazepine |
Should be used together with great caution. May significantly decrease fosamprenavir level in blood. |
| Clorazepate |
Should be used together with caution. May require decrease in clorazepate dose. |
| Cimetidine |
Should be used together with caution. May decrease fosamprenavir level in blood. No dose adjustment currently recommended. |
| Cisapride |
Should not be used together*. Increases risk of serious side effects. |
| Cyclosporine |
Should be used together with caution. May increase cyclosporine level in blood. Check cyclosporine level if used together. |
| Delavirdine |
Should not be used together. May significantly decrease fosamprenavir blood level. |
| Dexamethazone |
Should be used together with great caution. May significantly decrease fosamprenavir level in blood. |
| Diazepam |
Should be used together with caution. May require decrease in diazepam dose. |
| Dihydroergotamine |
Should not be used together*. Increases risk of side effects. |
| Efavirenz |
May significantly decrease fosamprenavir level in blood. Use only boosted fosamprenavir at 1,400 mg + 300 mg ritonavir once a day. |
| Ergonovine |
Should not be used together*. Increases risk of side effects. |
| Ergotamine |
Should not be used together*. Increases risk of side effects. |
| Famotidine |
Should be used together with caution. May decrease fosamprenavir level in blood. No dose adjustment currently recommended. |
| Flecainide |
Should not be used together if boosting with ritonavir*. Increases risk of serious side effects. |
| Flurazepam |
Should be used together with caution. May require decrease in flurazepam dose. |
| Itraconazole |
Should be used together with great caution. Increases risk of serious side effects. Do not exceed 400 mg of itraconazole if fosamprenavir used alone, or 200 mg if boosted with ritonavir. |
| Kaletra |
Significantly decreases fosamprenavir level in blood. Also increases risk of side effects. Appropriate dose adjustments not yet established. |
| Ketoconazole |
Should be used together with great caution. Increases risk of serious side effects. Do not exceed 400 mg of ketoconazole if fosamprenavir used alone, or 200 mg if boosted with ritonavir. |
| Lidocaine (systemic) |
Should be used together with great caution. May increase serious side effects. Check lidocaine blood concentrations if possible. |
| Lovastatin |
Should not be used together*. Increases risk of serious side effects. |
| Methylergonovine |
Should not be used together*. Increases risk of serious side effects. |
| Midazolam |
Should not be used together*. Increases risk of serious side effects. |
| Nizatidine |
Should be used together with caution. May decrease fosamprenavir level in blood. No dose adjustment currently recommended. |
| Phenobarbital |
Should be used together with great caution. |
| Phenytoin |
Should be used together with great caution. |
| Pimozide |
Should not be used together*. Increases risk of serious side effects. |
| Propafenone |
Should not be used together if boosting with ritonavir*. Increases risk of serious side effects. |
| Proton pump inhibitors |
Should be used together with great caution. May significantly decrease fosamprenavir level in blood. |
| Quinidine |
Should be used together with great caution. May increase serious side effects. Check quinidine blood concentrations if possible. |
| Ranitidine |
Should be used together with caution. Decreases fosamprenavir level by 51% in blood. No dose adjustment currently recommended. |
| Rapamycin |
Should be used together with caution. May increase rapamycin level in blood. Check rapamycin level if used together. |
| Rifabutin |
Should be used together with great caution. Increases risk of neutropenia. Check for side effects and decrease rifabutin dose by at least 50% if fosamprenavir used alone or by 75% if boosted with ritonavir. |
| Rifampin |
Should not be used together*. May decrease anti-HIV effect of fosamprenavir. |
| Ritonavir |
Increases fosamprenavir level in blood. Adjust dose to fosamprenavir 700 mg + ritonavir 100 mg twice a day or fosamprenavir 1,400 mg + ritonavir 200 mg once a day. |
| Sildenafil |
Should be used together with great caution. May increase risk of side effects. Decrease sildenafil dose to 25 mg every 48 hours and check for side effects. |
| Simvastatin |
Should not be used together*. Increases risk of serious side effects. |
| St. John's Wort |
Should not be used together. May significantly decrease fosamprenavir level in blood. |
| Tacrolimus |
Should be used together with caution. May increase tacrolimus level in blood. Check tacrolimus level if used together. |
| Tedalafil |
Should be used together with caution. May increase tedalafil level in blood. |
| Triazolam |
Should not be used together*. Increases risk of serious side effects. |
| Tricyclic antidepressants |
Should be used together with great caution. May increase risk of side effects. Check tricyclics level if used together. |
| Vardenafil |
Should be used together with great caution. May increase risk of side effects. Decrease vardenafil dose to 2.5 mg/24 hours (if fosamprenavir used alone) or 2.5 mg/72 hours (if boosted with ritonavir). Check for side effects. |
| Warfarin |
Should be used together with great caution. May increase risk of serious side effects. |
| Foscarnet (Foscavir) plus ... |
| Adefovir |
Should not be used together.* Increases risk of kidney toxicity. |
| Amikacin |
Should not be used together*. Increases risk of kidney toxicity. |
| Amphotericin B |
Should be used together with great caution. May decrease number of red blood cells and increases risk of kidney toxicity. |
| AZT |
Should be used together with caution. May increase risk of anemia. |
| Cidofovir |
Should not be used together*. Increases risk of kidney toxicity. |
| ddC |
May increase risk of kidney toxicity and peripheral neuropathy. Check for toxicity. |
| Gentamicin |
Should not be used together*. Increases risk of kidney toxicity. |
| Kanamycin |
Should not be used together*. Increases risk of kidney toxicity. |
| Pentamidine (IV) |
Should be used with caution. May increase risk of kidney toxicity. Check closely. |
| Ritonavir |
Should be used with caution. Abnormal kidney function has been observed. |
| Streptomycin |
Should be used together with great caution. Increases risk of kidney toxicity. |
| Tenofovir |
Should be used together with great caution. May increase risk of kidney toxicity. |
| Tobramycin |
Should not be used together*. Increases risk of kidney toxicity. |
| Ganciclovir (Cytovene, oral/IV) plus ... |
| Acyclovir |
People allergic to acyclovir should not take ganciclovir. |
| Adriamycin |
Should be used together with great caution. May increase risk of bone marrow toxicity. |
| Amphotericin B |
Should be used together with great caution. May increase risk of bone marrow toxicity. |
| Anticancer drugs |
May increase risk of bone marrow toxicity. |
| AZT |
Increases AZT level in blood and may increase risk of neutropenia, anemia and bone marrow toxicity. Avoid combination or lower AZT dose. |
| d4T |
May increase risk of pancreatitis. |
| Dapsone |
May increase risk of bone marrow toxicity. |
| ddI or ddI EC |
Should be used with caution. Significantly increases ddI level in blood. May increase risk of pancreatitis. |
| Food |
Increases oral ganciclovir level in blood. |
| Flucytosine |
Should be used together with great caution. May increase risk of bone marrow toxicity. |
| Imipenem-cilastin |
May increase risk of seizures. Check closely. |
| Interferon-alfa |
May increase risk of bone marrow toxicity. |
| Pentamidine |
Should be used together with great caution. May increase risk of bone marrow toxicity. |
| Probenecid |
Should be used together with caution. May increase ganciclovir level in blood and decrease ganciclovir clearance. |
| Tenofovir |
Should be used together with great caution. May increase risk of side effects. Check for kidney toxicity. |
| TMP/SMX |
Should be used together with great caution. May increase risk of bone marrow toxicity. |
| Vinblastine |
Should be used together with great caution. May increase risk of bone marrow toxicity. |
| Vincristine |
Should be used together with great caution. May increase risk of bone marrow toxicity. |
| Indinavir (Crixivan) plus ... |
| Amlodipine |
Should be used together with great caution. May increase amlodipine level in blood. |
| Amprenavir |
Increases amprenavir level by 33% and decreases indinavir level by 38% in blood. No dose adjustment recommended. |
| Astemizole |
Should not be used together*. Increases risk of side effects. |
| Atorvastatin |
Should be used together with great caution. May increase atorvastatin level in blood. |
| Atazanavir |
Should not be used together*. Increases risk of side effects. |
| AZT |
Increases AZT level 17–36% in blood. No dose adjustment recommended. |
| Benzodiazepines |
May increase benzodiazepine level in blood. |
| Bepridil |
Should be used together with great caution. May increase bepridil level in blood. |
| Cisapride |
Should not be used together*. Increases risk of side effects. |
| Clarithromycin |
Increases clarithromycin level by 53% and indinavir level by 29% in blood. No dose adjustment recommended. |
| ddI |
May decrease ddI and indinavir levels in blood. Indinavir should be taken 1 hour before or 2 hours after taking ddI. |
| Delavirdine |
Increases indinavir level 50–95% in blood. Indinavir may be reduced to 600 mg 3 times a day. |
| Dihydroergotamine |
Should not be used together*. Increases risk of side effects. |
| Diltiazem |
Should be used together with great caution. May increase diltiazem level in blood. |
| Efavirenz |
Decreases indinavir level by 31% in blood. Indinavir dose should be increased to 1,000 mg 3 times a day or 800 mg twice daily if boosted with ritonavir. |
| Ergonovine |
Should not be used together*. Increases risk of side effects. |
| Ergotamine |
Should not be used together*. Increases risk of side effects. |
| Ethinyl estradiol |
Should be used together with caution. Increases ethinyl estradiol level by 24% in blood. |
| Fatty foods |
Decreases indinavir level in blood. Indinavir should be taken 1 hour before eating or 2 hours after eating a large or fatty meal. Indinavir may be taken with a small snack such as juice and dry toast. |
| Felodipine |
Should be used together with great caution. May increase felodipine level in blood. |
| Fluconazole |
Decreases indinavir level by 19% in blood. |
| Fluvastatin |
Should be used together with great caution. May increase fluvastatin level in blood. |
| Grapefruit juice |
Decreases indinavir level by 26% in blood. |
| Isradipine |
Should be used together with great caution. May increase isradipine level in blood. |
| Itraconazole |
May affect indinavir and/or itraconazole level in blood. Decrease dose of indinavir to 600 mg 3 times a day when combined with itraconazole 200 mg twice daily. |
| Kaletra |
Increases indinavir trough level by about 4-fold in blood. Currently under study; however, indinavir dose should be reduced to no more than 600 mg twice a day if used together. |
| Ketoconazole |
Increases indinavir level by 68% in blood. Decrease indinavir dose to 600 mg 3 times a day. |
| Lovastatin |
Should not be used together*. Increases risk of side effects. |
| Methylergonovine |
Should not be used together*. Increases risk of side effects. |
| Midazolam |
Should not be used together*. Increases risk of side effects. |
| Nelfinavir |
Increases indinavir level by 51% and increases nelfinavir level by 83% in blood. There are limited data to support a dose of indinavir 1,200 mg + nelfinavir 1,250 mg twice a day. |
| Nevirapine |
Decreases indinavir level by 27% in blood. Indinavir dose should be increased to 1,000 mg 3 times a day or 800 mg twice daily if boosted with ritonavir. |
| Nicardipine |
Should be used together with great caution. May increase nicardipine level in blood. |
| Nifedipine |
Should be used together with great caution. May increase nifedipine level in blood. |
| Nimodipine |
Should be used together with great caution. May increase nimodipine level in blood. |
| Nisoldipine |
Should be used together with great caution. May increase nisoldipine level in blood. |
| Nitrendipine |
Should be used together with great caution. May increase nitrendipine level in blood. |
| Norethindrone |
Should be used together with caution. Increases norethindrone level in blood by 14%. |
| Quinidine |
Increases indinavir level by 10% in blood. |
| Rifabutin |
Increases rifabutin level by 204% and decreases indinavir level by 32% in blood. Decrease dose of rifabutin by half the standard dose and increase indinavir dose to 1,000 mg 3 times a day. |
| Rifampin |
Should not be used together*. May increase rifampin level in blood. |
| Rifampicin |
Should not be used together. Decreases indinavir level by 80% in blood, even when boosted with ritonavir. |
| Ritonavir |
Significantly increases indinavir level in blood. Adjust dose to indinavir 800 mg + ritonavir 200 mg twice a day or indinavir 400 mg + ritonavir 400 mg twice a day. |
| Saquinavir (Fortovase) |
Increases saquinavir level 3.6–6.2 times in blood. |
| Saquinavir (Invirase) |
Increases saquinavir level 4.6–7.2 times in blood. |
| Sildenafil |
Should be used with caution. Increases indinavir and sildenafil levels in blood. |
| Simvastatin |
Should not be used together*. Increases risk of side effects. |
| St. John's Wort |
Should not be used together. Decreases indinavir level by 57% in blood. |
| Tedalafil |
Should be used together with caution. May increase tedalafil level in blood. |
| TMP/SMX |
Should be used together with caution. Increases trimethoprim level by 31% in blood. |
| Triazolam |
Should not be used together*. Increases risk of side effects. |
| Vardenafil |
Should be used together with caution. Increases vardenafil level in blood. Dose of vardenafil should not exceed 2.5 mg/day. |
| Verapamil |
Should be used together with great caution. May increase verapamil level in blood. |
| Isoniazid (INH) plus ... |
| Acetaminophen |
Should not be used together*. Increases risk of side effects. |
| Alcohol |
Daily or heavy alcohol use may increase risk of isoniazid-associated hepatitis. |
| Carbamazepine |
Should be used together with great caution. Increases carbamazepine level in blood. Check for toxicity and adjust carbamazepine dose accordingly. |
| Corticosteroids |
Increases isoniazid metabolism and decreases isoniazid level in blood. Isoniazid dose may require adjustment. |
| Cycloserine |
May increase risk of central nervous system toxicity. |
| ddC |
May increase risk of peripheral neuropathy. |
| Ethionamide |
May increase risk of encephalopathy (dysfunction of the brain) and may increase isoniazid level in blood. |
| Food |
Should not be used together. Decreases isoniazid level in blood. |
| Itraconazole |
Should be used together with great caution. May decrease itraconazole level in blood. |
| Ketoconazole |
Should not be used together*. Decreases ketoconazole level in blood. |
| Phenytoin |
Should be used together with caution. Increases phenytoin level in blood. Check for toxicity and adjust dose of phenytoin accordingly. |
| Rifampin |
Should be used together with caution. May increase risk of liver toxicity. |
| Sulfonylureas |
May increase risk of high blood sugar level. |
| Theophylline |
Should be used together with great caution. Increases level of theophylline in blood. Check theophylline level closely. |
| Itraconazole (Sporanox) plus ... |
| Alprazolam |
Should be used together with caution. May increase level of alprazolam in blood. Check for side effects. |
| Amphotericin B |
May interfere with activity of amphotericin B. |
| Amprenavir |
May increase itraconazole and amprenavir levels in blood. Check for side effects. |
| Antacids |
Decreases itraconazole level in blood. Should be taken 2 hours apart. |
| Astemizole |
Should not be used together*. Increases risk of side effects. |
| Atorvastatin |
Should not be used together*. Increases risk of side effects. |
| Busulfan |
Should be used together with caution. Increases busulfan level in blood. Check for toxicity. |
| Carbamazepine |
Should be used together with caution. Increases carbamazepine level and decreases itraconazole level in blood. Check for side effects. |
| Cimetidine |
Decreases itraconazole level in blood. May need to be taken at least 2 hours apart. |
| Cisapride |
Should not be used together*. Increases risk of side effects. |
| Cola beverage |
Should be used together with caution. Increases itraconazole level 75% in blood. |
| Cyclosporine |
Should be used together with caution. Increases cyclosporine level in blood and may increase risk of side effects. |
| ddI |
Needs to be taken 2 hours apart, otherwise ddI buffering agents may significantly decrease itraconazole level in blood. |
| Delavirdine |
May increase delavirdine level in blood. |
| Diazepam |
Should be used together with caution. May increase level of diazepam in blood. Check for side effects. |
| Digoxin |
Should be used together with caution. Increases digoxin level in blood. Check for side effects. |
| Dofetilide |
Should not be used together*. Increases dofetilide level in blood. |
| Felodipine |
Should be used together with great caution. Increases risk of felodipine side effects. Check closely. |
| Fluvastatin |
Should not be used together*. Increases risk of side effects. |
| Food |
May increase itraconazole level in blood. |
| Fosamprenavir |
Should be used together with great caution. Increases risk of serious side effects. Do not exceed 400 mg of itraconazole if fosamprenavir used alone, or 200 mg if boosted with ritonavir. |
| Glipizide |
May increase risk of low blood sugar level. |
| Glyburide |
May increase risk of low blood sugar level. |
| Indinavir |
May affect itraconazole and/or indinavir level in blood. Reduce dose of indinavir to 600 mg 3 times a day when combined with itraconazole 200 mg twice daily. |
| Isoniazid |
Should be used together with great caution. May decrease itraconazole level in blood. |
| Kaletra |
Increases itraconazole level in blood. Dose of itraconazole should not exceed 200 mg/day. |
| Lovastatin |
Should not be used together*. Increases risk of side effects. |
| Midazolam (oral) |
Should not be used together*. Increases risk of side effects. |
| Nevirapine |
Should be used together with caution. May decrease itraconazole level in blood. Itraconazole dose may need to be increased. |
| Nicardipine |
Should be used together with great caution. Increases risk of nicardipine side effects. Check closely. |
| Nifedipine |
Should be used together with great caution. Increases risk of nifedipine side effects. Check closely. |
| Nimodipine |
Should be used together with great caution. Increases risk of nimodipine side effects. Check closely. |
| Nisoldipine |
Should be used together with great caution. Increases risk of nisoldipine side effects. Check closely. |
| Nitrendipine |
Should be used together with great caution. Increases risk of nitrendipine side effects. Check closely. |
| Omeprazole |
Decreases itraconazole level in blood. |
| Phenobarbital |
Should be used together with caution. Decreases itraconazole level and may increase phenobarbital level in blood. |
| Phenytoin |
Should be used together with caution. Decreases itraconazole level and may increase phenytoin level in blood. |
| Pimozide |
Should not be used together*. Increases risk of side effects. |
| Quinidine |
Should not be used together*. Increases risk of side effects. |
| Ranitidine |
Decreases itraconazole level in blood. |
| Rifabutin |
Should not be used together. May increase rifabutin level and may decrease itraconazole level in blood. |
| Rifampin |
Should not be used together. Decreases rifampin level and may decrease itraconazole level in blood. |
| Ritonavir |
Should be used together with caution. May significantly increase itraconazole level in blood. |
| Saquinavir (Fortovase) |
Increases saquinavir level in blood. However, no dose adjustment recommended. |
| Saquinavir (Invirase) |
Increases saquinavir level in blood. However, no dose adjustment recommended. |
| Simvastatin |
Should not be used together*. Increases risk of side effects. |
| Sirolimus |
Should be used together with caution. Increases sirolimus level in blood. |
| Tacrolimus |
Should be used together with caution. Increases tacrolimus level in blood. |
| Tedalafil |
Should be used together with caution. Increases tedalafil level in blood. Tedalafil dose should not exceed 10 mg in a 72 hour period. |
| Testosterone |
May decrease testosterone level in blood. |
| Tolbutamide |
May increase risk of low blood sugar level. |
| Trazodone |
Increases trazodone level in blood. Trazodone dose may need to be reduced. |
| Triazolam |
Should not be used together*. Increases risk of side effects. |
| Trimetrexate |
May affect trimetrexate and/or itraconazole level in blood. |
| Vardenafil |
Should be used together with caution. Increases vardenafil level in blood. If taking 400 mg itraconazole per day, dose of vardenafil should not exceed 2.5 mg/day. If taking 200 mg itraconazole per day, dose of vardenafil should not exceed 5 mg/day. |
| Verapamil |
Should be used together with great caution. Increases risk of verapamil side effects. Check closely. |
| Vinblastine |
Should be used together with caution. Increases vinblastine level in blood. Check for side effects. |
| Vincristine |
Should be used together with caution. Increases vincristine level in blood. Check for side effects. |
| Warfarin |
Should be used together with caution. May increase prothrombin (coagulation) time and increase anticoagulant effects. Check warfarin dose closely. |
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