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Anti-HIV Drug Interactions

A Guide to the Interactions Found Between Anti-HIV Drugs and Common HIV-Related Therapies

August 2004

A note from TheBody.com: Since this article was written, the HIV pandemic has changed, as has our understanding of HIV/AIDS and its treatment. As a result, parts of this article may be outdated. Please keep this in mind, and be sure to visit other parts of our site for more recent information!

Interactions Table (E-I)

A | B-D | K-P | R | S-Z


Efavirenz (Sustiva) plus ...
Amprenavir Decreases amprenavir level by 36% and increases efavirenz level by 15% in blood. Amprenavir dose may need to be increased.
Atazanavir Decreases atazanavir level in blood. Atazanavir should be boosted with ritonavir if used with efavirenz.
Atorvastatin Decreases atorvastatin level in blood. Atorvastatin dose may need to be increased.
Clarithromycin Slightly increases efavirenz level but decreases clarithromycin level by 39% (increases 14-hydroxy clarithromycin level by 34%) in blood. No dose adjustment currently recommended.
Fluconazole Increases efavirenz level by 16% in blood. No dose adjustment currently recommended.
Food Should be taken on an empty stomach. Increases efavirenz level 10–50% in blood.
Fosamprenavir May significantly decrease fosamprenavir level in blood. Use only boosted fosamprenavir at 1,400 mg + 300 mg ritonavir once a day.
Indinavir Decreases indinavir level by 31% in blood. Indinavir dose should be increased to 1,000 mg 3 times a day or 800 mg twice daily if boosted with ritonavir.
Kaletra Decreases lopinavir level by about 25% (trough by about 33%). Kaletra dose should be increased to 4 capsules twice a day.
Methadone Decreases methadone level by 52% in blood. Check for methadone withdrawal symptoms and adjust methadone dose accordingly.
Nelfinavir Increases nelfinavir level by 20% and decreases efavirenz level by 22% in blood. No dose adjustments currently recommended.
Nevirapine Decreases efavirenz level by 22% in blood. Efavirenz dose may need to be increased to 800 mg once a day.
Rifabutin Decreases rifabutin level in blood. Increase rifabutin dose by 50% if taken daily or double the dose if taken 3 times a week.
Rifampin Decreases efavirenz level by 26% in blood. Impact of interaction is uncertain.
Ritonavir Should be used together with caution. Increases efavirenz level by 21% and ritonavir level by 18% in blood. Check for side effects.
Saquinavir (Fortovase) Decreases efavirenz level by 12% and decreases saquinavir level by 62% in blood. Requires ritonavir boosting.
St. John's Wort Should be used together with great caution. May decrease efavirenz level in blood.
Simvastatin Decreases simvastatin level in blood. Simvastatin dose may need to be increased.
Voriconazole Should not be used together. Increases risk of side effects.

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Emtricitabine (FTC, Emtriva) plus ...
There are currently no known or suspected interactions between FTC and any other drugs.

Enfuvirtide (T20, Fuzeon) plus ...
There are currently no known or suspected interactions between enfuvirtide and any other drugs, although ritonavir can increase enfuvirtide level in blood somewhat.

Ethinyl estradiol (Ortho-Novum) plus ...
Amprenavir Should not be used together. May decrease ethinyl estradiol and norethindrone levels in blood. Use another form of contraception.
Atazanavir Should be used together with caution. Increases ethinyl estradiol level in blood. Use lowest effective dose of ethinyl estradiol.
Delavirdine May increase ethinyl estradiol level in blood. Impact of interaction is uncertain.
Fluconazole Increases ethinyl estradiol level by up to 38% in blood. No dose adjustments currently recommended.
Indinavir Should be used together with caution. Increases ethinyl estradiol level by 24% in blood.
Kaletra Should not be used together. Decreases ethinyl estradiol level by 42% in blood. Use another form of contraception.
Nelfinavir Should not be used together. Decreases ethinyl estradiol level by 47% in blood. Use another form of contraception.
Nevirapine Should not be used together. Decreases ethinyl estradiol level in blood. Use another form of contraception.
Rifabutin Should not be used together. May decrease ethinyl estradiol level in blood. Use another form of contraception.
Rifampin Should not be used together. May decrease ethinyl estradiol level in blood. Use another form of contraception.
Ritonavir Should not be used together. Decreases ethinyl estradiol level by 40% in blood. Use an another form of contraception.

Ethionamide (Trecator) plus ...
Alcohol Excessive alcohol consumption while on ethionamide may cause psychosis.
Cycloserine May increase risk of central nervous system related toxicity.
ddC May increase risk of peripheral neuropathy.
Ethambutol May increase risk of side effects from other anti-TB drugs like ethambutol.
Isoniazid May increase risk of encephalopathy (dysfunction of brain). May increase isoniazid level in blood.
Pyrazinamide May increase risk of side effects from other anti-TB drugs like pyrazinamide.
Rifabutin May increase risk of side effects from other anti-TB drugs like rifabutin.
Rifampin May increase risk of side effects from other anti-TB drugs like rifampin.
Rifapentine May increase risk of side effects from other anti-TB drugs like rifapentine.

Fluconazole (Diflucan) plus ...
Amphotericin B May interfere with the activity of amphotericin B.
Astemizole Should not be used together*. Increases risk of side effects.
AZT Increases AZT level by 74% and may increase fluconazole level in blood. Check for toxicity.
Benzodiazepines May increase benzodiazepine level in blood.
Cimetidine Decreases fluconazole level by 13% in blood. No dose adjustment recommended.
Cisapride Should not be used together*. Increases risk of side effects.
Cyclosporine Should be used together with caution. Increases cyclosporine level by 92% in blood. Check cyclosporine level and serum creatinine.
Efavirenz Increases efavirenz level by 16% in blood. No dose adjustment currently recommended.
Ethinyl estradiol Increases ethinyl estradiol level by up to 38% in blood. No dose adjustments currently recommended.
Glipizide Should be used together with caution. Increases glipizide level by 49% in blood. Closely check blood sugar for hypoglycemia.
Glyburide Should be used together with caution. Increases glyburide level by 44% in blood. Closely check blood sugar for hypoglycemia.
Hydrochlorothiazide Increases fluconazole level by 45% in blood.
Indinavir Decreases indinavir level by 19% in blood.
Levonorgestrel Increases levonorgestrel level by 25% in blood.
Loratadine May affect loratadine and/or fluconazole level in blood.
Phenytoin Increases phenytoin level by 88% in blood.
Ranitidine May decrease fluconazole level in blood.
Rifabutin Should be used together with caution. May increase rifabutin level by up to 80% in blood. Increases risk of painful eye inflammation.
Rifampin Should be used together with caution. Decreases fluconazole level by 23% in blood. May require higher dose of fluconazole.
Ritonavir Increases ritonavir level by 12% in blood. No dose adjustment recommended; however, check for liver toxicity.
Saquinavir (Fortovase) May increase saquinavir level in blood. However, no dose adjustment recommended.
Saquinavir (Invirase) May increase saquinavir level in blood. However, no dose adjustment recommended.
Tacrolimus Should be used together with caution. May increase tacrolimus level in blood and increases risk of kidney toxicity.
Theophylline Should be used together with caution. Increases theophylline level by 21% in blood. Check theophylline level.
Tolbutamide Should be used together with caution. Increases tolbutamide level by 26% in blood. Closely check blood sugar for hypoglycemia.
Trimetrexate May affect trimetrexate and/or fluconazole level in blood.
Warfarin Should be used together with caution. Check for increases in prothrombin (coagulation) time.

Flucytosine (Ancobon) plus ...
Amphotericin B Increases antifungal activity in test tubes but increases risk of bone marrow and kidney toxicity.
AZT May increase risk of bone marrow toxicity.
Cytosine arabinoside Should be used with caution. May decrease antifungal activity.
Ganciclovir Should be used together with great caution. May increase risk of bone marrow toxicity.
Interferon-alfa May increase risk of bone marrow toxicity.

Fosamprenavir (Lexiva) plus ...
Alprazolam Should be used together with caution. May require decrease in alprazolam dose.
Amiodarone Should be used together with great caution. May increase serious side effects. Check amiodarone blood concentrations if possible.
Atorvastatin Fosamprenavir alone and with ritonavir increases atorvastatin level in blood. Lower atorvastatin dose to no more than 20 mg/day or use alternatives.
Bepridil Should be used together with great caution. Increases risk of serious side effects.
Calcium channel blockers Should be used together with great caution. Check for side effects.
Carbamazepine Should be used together with great caution. May significantly decrease fosamprenavir level in blood.
Clorazepate Should be used together with caution. May require decrease in clorazepate dose.
Cimetidine Should be used together with caution. May decrease fosamprenavir level in blood. No dose adjustment currently recommended.
Cisapride Should not be used together*. Increases risk of serious side effects.
Cyclosporine Should be used together with caution. May increase cyclosporine level in blood. Check cyclosporine level if used together.
Delavirdine Should not be used together. May significantly decrease fosamprenavir blood level.
Dexamethazone Should be used together with great caution. May significantly decrease fosamprenavir level in blood.
Diazepam Should be used together with caution. May require decrease in diazepam dose.
Dihydroergotamine Should not be used together*. Increases risk of side effects.
Efavirenz May significantly decrease fosamprenavir level in blood. Use only boosted fosamprenavir at 1,400 mg + 300 mg ritonavir once a day.
Ergonovine Should not be used together*. Increases risk of side effects.
Ergotamine Should not be used together*. Increases risk of side effects.
Famotidine Should be used together with caution. May decrease fosamprenavir level in blood. No dose adjustment currently recommended.
Flecainide Should not be used together if boosting with ritonavir*. Increases risk of serious side effects.
Flurazepam Should be used together with caution. May require decrease in flurazepam dose.
Itraconazole Should be used together with great caution. Increases risk of serious side effects. Do not exceed 400 mg of itraconazole if fosamprenavir used alone, or 200 mg if boosted with ritonavir.
Kaletra Significantly decreases fosamprenavir level in blood. Also increases risk of side effects. Appropriate dose adjustments not yet established.
Ketoconazole Should be used together with great caution. Increases risk of serious side effects. Do not exceed 400 mg of ketoconazole if fosamprenavir used alone, or 200 mg if boosted with ritonavir.
Lidocaine (systemic) Should be used together with great caution. May increase serious side effects. Check lidocaine blood concentrations if possible.
Lovastatin Should not be used together*. Increases risk of serious side effects.
Methylergonovine Should not be used together*. Increases risk of serious side effects.
Midazolam Should not be used together*. Increases risk of serious side effects.
Nizatidine Should be used together with caution. May decrease fosamprenavir level in blood. No dose adjustment currently recommended.
Phenobarbital Should be used together with great caution.
Phenytoin Should be used together with great caution.
Pimozide Should not be used together*. Increases risk of serious side effects.
Propafenone Should not be used together if boosting with ritonavir*. Increases risk of serious side effects.
Proton pump inhibitors Should be used together with great caution. May significantly decrease fosamprenavir level in blood.
Quinidine Should be used together with great caution. May increase serious side effects. Check quinidine blood concentrations if possible.
Ranitidine Should be used together with caution. Decreases fosamprenavir level by 51% in blood. No dose adjustment currently recommended.
Rapamycin Should be used together with caution. May increase rapamycin level in blood. Check rapamycin level if used together.
Rifabutin Should be used together with great caution. Increases risk of neutropenia. Check for side effects and decrease rifabutin dose by at least 50% if fosamprenavir used alone or by 75% if boosted with ritonavir.
Rifampin Should not be used together*. May decrease anti-HIV effect of fosamprenavir.
Ritonavir Increases fosamprenavir level in blood. Adjust dose to fosamprenavir 700 mg + ritonavir 100 mg twice a day or fosamprenavir 1,400 mg + ritonavir 200 mg once a day.
Sildenafil Should be used together with great caution. May increase risk of side effects. Decrease sildenafil dose to 25 mg every 48 hours and check for side effects.
Simvastatin Should not be used together*. Increases risk of serious side effects.
St. John's Wort Should not be used together. May significantly decrease fosamprenavir level in blood.
Tacrolimus Should be used together with caution. May increase tacrolimus level in blood. Check tacrolimus level if used together.
Tedalafil Should be used together with caution. May increase tedalafil level in blood.
Triazolam Should not be used together*. Increases risk of serious side effects.
Tricyclic antidepressants Should be used together with great caution. May increase risk of side effects. Check tricyclics level if used together.
Vardenafil Should be used together with great caution. May increase risk of side effects. Decrease vardenafil dose to 2.5 mg/24 hours (if fosamprenavir used alone) or 2.5 mg/72 hours (if boosted with ritonavir). Check for side effects.
Warfarin Should be used together with great caution. May increase risk of serious side effects.

Foscarnet (Foscavir) plus ...
Adefovir Should not be used together.* Increases risk of kidney toxicity.
Amikacin Should not be used together*. Increases risk of kidney toxicity.
Amphotericin B Should be used together with great caution. May decrease number of red blood cells and increases risk of kidney toxicity.
AZT Should be used together with caution. May increase risk of anemia.
Cidofovir Should not be used together*. Increases risk of kidney toxicity.
ddC May increase risk of kidney toxicity and peripheral neuropathy. Check for toxicity.
Gentamicin Should not be used together*. Increases risk of kidney toxicity.
Kanamycin Should not be used together*. Increases risk of kidney toxicity.
Pentamidine (IV) Should be used with caution. May increase risk of kidney toxicity. Check closely.
Ritonavir Should be used with caution. Abnormal kidney function has been observed.
Streptomycin Should be used together with great caution. Increases risk of kidney toxicity.
Tenofovir Should be used together with great caution. May increase risk of kidney toxicity.
Tobramycin Should not be used together*. Increases risk of kidney toxicity.

Ganciclovir (Cytovene, oral/IV) plus ...
Acyclovir People allergic to acyclovir should not take ganciclovir.
Adriamycin Should be used together with great caution. May increase risk of bone marrow toxicity.
Amphotericin B Should be used together with great caution. May increase risk of bone marrow toxicity.
Anticancer drugs May increase risk of bone marrow toxicity.
AZT Increases AZT level in blood and may increase risk of neutropenia, anemia and bone marrow toxicity. Avoid combination or lower AZT dose.
d4T May increase risk of pancreatitis.
Dapsone May increase risk of bone marrow toxicity.
ddI or ddI EC Should be used with caution. Significantly increases ddI level in blood. May increase risk of pancreatitis.
Food Increases oral ganciclovir level in blood.
Flucytosine Should be used together with great caution. May increase risk of bone marrow toxicity.
Imipenem-cilastin May increase risk of seizures. Check closely.
Interferon-alfa May increase risk of bone marrow toxicity.
Pentamidine Should be used together with great caution. May increase risk of bone marrow toxicity.
Probenecid Should be used together with caution. May increase ganciclovir level in blood and decrease ganciclovir clearance.
Tenofovir Should be used together with great caution. May increase risk of side effects. Check for kidney toxicity.
TMP/SMX Should be used together with great caution. May increase risk of bone marrow toxicity.
Vinblastine Should be used together with great caution. May increase risk of bone marrow toxicity.
Vincristine Should be used together with great caution. May increase risk of bone marrow toxicity.

Indinavir (Crixivan) plus ...
Amlodipine Should be used together with great caution. May increase amlodipine level in blood.
Amprenavir Increases amprenavir level by 33% and decreases indinavir level by 38% in blood. No dose adjustment recommended.
Astemizole Should not be used together*. Increases risk of side effects.
Atorvastatin Should be used together with great caution. May increase atorvastatin level in blood.
Atazanavir Should not be used together*. Increases risk of side effects.
AZT Increases AZT level 17–36% in blood. No dose adjustment recommended.
Benzodiazepines May increase benzodiazepine level in blood.
Bepridil Should be used together with great caution. May increase bepridil level in blood.
Cisapride Should not be used together*. Increases risk of side effects.
Clarithromycin Increases clarithromycin level by 53% and indinavir level by 29% in blood. No dose adjustment recommended.
ddI May decrease ddI and indinavir levels in blood. Indinavir should be taken 1 hour before or 2 hours after taking ddI.
Delavirdine Increases indinavir level 50–95% in blood. Indinavir may be reduced to 600 mg 3 times a day.
Dihydroergotamine Should not be used together*. Increases risk of side effects.
Diltiazem Should be used together with great caution. May increase diltiazem level in blood.
Efavirenz Decreases indinavir level by 31% in blood. Indinavir dose should be increased to 1,000 mg 3 times a day or 800 mg twice daily if boosted with ritonavir.
Ergonovine Should not be used together*. Increases risk of side effects.
Ergotamine Should not be used together*. Increases risk of side effects.
Ethinyl estradiol Should be used together with caution. Increases ethinyl estradiol level by 24% in blood.
Fatty foods Decreases indinavir level in blood. Indinavir should be taken 1 hour before eating or 2 hours after eating a large or fatty meal. Indinavir may be taken with a small snack such as juice and dry toast.
Felodipine Should be used together with great caution. May increase felodipine level in blood.
Fluconazole Decreases indinavir level by 19% in blood.
Fluvastatin Should be used together with great caution. May increase fluvastatin level in blood.
Grapefruit juice Decreases indinavir level by 26% in blood.
Isradipine Should be used together with great caution. May increase isradipine level in blood.
Itraconazole May affect indinavir and/or itraconazole level in blood. Decrease dose of indinavir to 600 mg 3 times a day when combined with itraconazole 200 mg twice daily.
Kaletra Increases indinavir trough level by about 4-fold in blood. Currently under study; however, indinavir dose should be reduced to no more than 600 mg twice a day if used together.
Ketoconazole Increases indinavir level by 68% in blood. Decrease indinavir dose to 600 mg 3 times a day.
Lovastatin Should not be used together*. Increases risk of side effects.
Methylergonovine Should not be used together*. Increases risk of side effects.
Midazolam Should not be used together*. Increases risk of side effects.
Nelfinavir Increases indinavir level by 51% and increases nelfinavir level by 83% in blood. There are limited data to support a dose of indinavir 1,200 mg + nelfinavir 1,250 mg twice a day.
Nevirapine Decreases indinavir level by 27% in blood. Indinavir dose should be increased to 1,000 mg 3 times a day or 800 mg twice daily if boosted with ritonavir.
Nicardipine Should be used together with great caution. May increase nicardipine level in blood.
Nifedipine Should be used together with great caution. May increase nifedipine level in blood.
Nimodipine Should be used together with great caution. May increase nimodipine level in blood.
Nisoldipine Should be used together with great caution. May increase nisoldipine level in blood.
Nitrendipine Should be used together with great caution. May increase nitrendipine level in blood.
Norethindrone Should be used together with caution. Increases norethindrone level in blood by 14%.
Quinidine Increases indinavir level by 10% in blood.
Rifabutin Increases rifabutin level by 204% and decreases indinavir level by 32% in blood. Decrease dose of rifabutin by half the standard dose and increase indinavir dose to 1,000 mg 3 times a day.
Rifampin Should not be used together*. May increase rifampin level in blood.
Rifampicin Should not be used together. Decreases indinavir level by 80% in blood, even when boosted with ritonavir.
Ritonavir Significantly increases indinavir level in blood. Adjust dose to indinavir 800 mg + ritonavir 200 mg twice a day or indinavir 400 mg + ritonavir 400 mg twice a day.
Saquinavir (Fortovase) Increases saquinavir level 3.6–6.2 times in blood.
Saquinavir (Invirase) Increases saquinavir level 4.6–7.2 times in blood.
Sildenafil Should be used with caution. Increases indinavir and sildenafil levels in blood.
Simvastatin Should not be used together*. Increases risk of side effects.
St. John's Wort Should not be used together. Decreases indinavir level by 57% in blood.
Tedalafil Should be used together with caution. May increase tedalafil level in blood.
TMP/SMX Should be used together with caution. Increases trimethoprim level by 31% in blood.
Triazolam Should not be used together*. Increases risk of side effects.
Vardenafil Should be used together with caution. Increases vardenafil level in blood. Dose of vardenafil should not exceed 2.5 mg/day.
Verapamil Should be used together with great caution. May increase verapamil level in blood.

Interferon-alfa (Intron-A, Roferon-A) plus ...
Anticancer drugs May increase risk of bone marrow toxicity.
AZT Increases anti-HIV activity in test tubes and may increase risk of bone marrow toxicity. Lower AZT dose by 50–75%.
Flucytosine May increase risk of bone marrow toxicity.
Ganciclovir May increase risk of bone marrow toxicity.
Pentamidine May increase risk of bone marrow toxicity.
Pyrimethamine May increase risk of bone marrow toxicity.

Isoniazid (INH) plus ...
Acetaminophen Should not be used together*. Increases risk of side effects.
Alcohol Daily or heavy alcohol use may increase risk of isoniazid-associated hepatitis.
Carbamazepine Should be used together with great caution. Increases carbamazepine level in blood. Check for toxicity and adjust carbamazepine dose accordingly.
Corticosteroids Increases isoniazid metabolism and decreases isoniazid level in blood. Isoniazid dose may require adjustment.
Cycloserine May increase risk of central nervous system toxicity.
ddC May increase risk of peripheral neuropathy.
Ethionamide May increase risk of encephalopathy (dysfunction of the brain) and may increase isoniazid level in blood.
Food Should not be used together. Decreases isoniazid level in blood.
Itraconazole Should be used together with great caution. May decrease itraconazole level in blood.
Ketoconazole Should not be used together*. Decreases ketoconazole level in blood.
Phenytoin Should be used together with caution. Increases phenytoin level in blood. Check for toxicity and adjust dose of phenytoin accordingly.
Rifampin Should be used together with caution. May increase risk of liver toxicity.
Sulfonylureas May increase risk of high blood sugar level.
Theophylline Should be used together with great caution. Increases level of theophylline in blood. Check theophylline level closely.

Itraconazole (Sporanox) plus ...
Alprazolam Should be used together with caution. May increase level of alprazolam in blood. Check for side effects.
Amphotericin B May interfere with activity of amphotericin B.
Amprenavir May increase itraconazole and amprenavir levels in blood. Check for side effects.
Antacids Decreases itraconazole level in blood. Should be taken 2 hours apart.
Astemizole Should not be used together*. Increases risk of side effects.
Atorvastatin Should not be used together*. Increases risk of side effects.
Busulfan Should be used together with caution. Increases busulfan level in blood. Check for toxicity.
Carbamazepine Should be used together with caution. Increases carbamazepine level and decreases itraconazole level in blood. Check for side effects.
Cimetidine Decreases itraconazole level in blood. May need to be taken at least 2 hours apart.
Cisapride Should not be used together*. Increases risk of side effects.
Cola beverage Should be used together with caution. Increases itraconazole level 75% in blood.
Cyclosporine Should be used together with caution. Increases cyclosporine level in blood and may increase risk of side effects.
ddI Needs to be taken 2 hours apart, otherwise ddI buffering agents may significantly decrease itraconazole level in blood.
Delavirdine May increase delavirdine level in blood.
Diazepam Should be used together with caution. May increase level of diazepam in blood. Check for side effects.
Digoxin Should be used together with caution. Increases digoxin level in blood. Check for side effects.
Dofetilide Should not be used together*. Increases dofetilide level in blood.
Felodipine Should be used together with great caution. Increases risk of felodipine side effects. Check closely.
Fluvastatin Should not be used together*. Increases risk of side effects.
Food May increase itraconazole level in blood.
Fosamprenavir Should be used together with great caution. Increases risk of serious side effects. Do not exceed 400 mg of itraconazole if fosamprenavir used alone, or 200 mg if boosted with ritonavir.
Glipizide May increase risk of low blood sugar level.
Glyburide May increase risk of low blood sugar level.
Indinavir May affect itraconazole and/or indinavir level in blood. Reduce dose of indinavir to 600 mg 3 times a day when combined with itraconazole 200 mg twice daily.
Isoniazid Should be used together with great caution. May decrease itraconazole level in blood.
Kaletra Increases itraconazole level in blood. Dose of itraconazole should not exceed 200 mg/day.
Lovastatin Should not be used together*. Increases risk of side effects.
Midazolam (oral) Should not be used together*. Increases risk of side effects.
Nevirapine Should be used together with caution. May decrease itraconazole level in blood. Itraconazole dose may need to be increased.
Nicardipine Should be used together with great caution. Increases risk of nicardipine side effects. Check closely.
Nifedipine Should be used together with great caution. Increases risk of nifedipine side effects. Check closely.
Nimodipine Should be used together with great caution. Increases risk of nimodipine side effects. Check closely.
Nisoldipine Should be used together with great caution. Increases risk of nisoldipine side effects. Check closely.
Nitrendipine Should be used together with great caution. Increases risk of nitrendipine side effects. Check closely.
Omeprazole Decreases itraconazole level in blood.
Phenobarbital Should be used together with caution. Decreases itraconazole level and may increase phenobarbital level in blood.
Phenytoin Should be used together with caution. Decreases itraconazole level and may increase phenytoin level in blood.
Pimozide Should not be used together*. Increases risk of side effects.
Quinidine Should not be used together*. Increases risk of side effects.
Ranitidine Decreases itraconazole level in blood.
Rifabutin Should not be used together. May increase rifabutin level and may decrease itraconazole level in blood.
Rifampin Should not be used together. Decreases rifampin level and may decrease itraconazole level in blood.
Ritonavir Should be used together with caution. May significantly increase itraconazole level in blood.
Saquinavir (Fortovase) Increases saquinavir level in blood. However, no dose adjustment recommended.
Saquinavir (Invirase) Increases saquinavir level in blood. However, no dose adjustment recommended.
Simvastatin Should not be used together*. Increases risk of side effects.
Sirolimus Should be used together with caution. Increases sirolimus level in blood.
Tacrolimus Should be used together with caution. Increases tacrolimus level in blood.
Tedalafil Should be used together with caution. Increases tedalafil level in blood. Tedalafil dose should not exceed 10 mg in a 72 hour period.
Testosterone May decrease testosterone level in blood.
Tolbutamide May increase risk of low blood sugar level.
Trazodone Increases trazodone level in blood. Trazodone dose may need to be reduced.
Triazolam Should not be used together*. Increases risk of side effects.
Trimetrexate May affect trimetrexate and/or itraconazole level in blood.
Vardenafil Should be used together with caution. Increases vardenafil level in blood. If taking 400 mg itraconazole per day, dose of vardenafil should not exceed 2.5 mg/day. If taking 200 mg itraconazole per day, dose of vardenafil should not exceed 5 mg/day.
Verapamil Should be used together with great caution. Increases risk of verapamil side effects. Check closely.
Vinblastine Should be used together with caution. Increases vinblastine level in blood. Check for side effects.
Vincristine Should be used together with caution. Increases vincristine level in blood. Check for side effects.
Warfarin Should be used together with caution. May increase prothrombin (coagulation) time and increase anticoagulant effects. Check warfarin dose closely.


Interpreting Directions

Should not be used together
The risk of side effects from a combination is too high for the two medications to be used together.

An asterisk (*) following this phrase means the side effects may be life-threatening.

Should be used together with caution
The risk of side effects from a combination is possible, but not highly common.

Should be used together with great caution
The risk of side effects from a combination is possible, and though not common may be serious if they occur.

A note from TheBody.com: Since this article was written, the HIV pandemic has changed, as has our understanding of HIV/AIDS and its treatment. As a result, parts of this article may be outdated. Please keep this in mind, and be sure to visit other parts of our site for more recent information!




  
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