| Amphotericin B (Fungizone) plus ... |
| Adefovir |
Should not be used together.* Increases risk of kidney toxicity. |
| Amikacin |
Should be used together with great caution. May increase risk of kidney toxicity. |
| Anticancer drugs |
Should be used together with great caution. May increase risk of kidney toxicity and low blood pressure. |
| AZT |
May increase risk of bone marrow toxicity. |
| Cidofovir |
Should not be used together*. Increases risk of kidney toxicity. |
| Clotrimazole |
May interfere with the activity of amphotericin B. |
| Corticosteroids |
Should be used together with caution. May decrease potassium level and increases risk of heart problems. |
| Cyclosporine |
Should be used together with great caution. May increase risk of kidney toxicity. |
| ddC |
May increase ddC level in blood and increase risk of peripheral neuropathy. |
| Digitalis |
Use together with great caution. May increase risk of heart problems. |
| Fluconazole |
May interfere with the activity of amphotericin B. |
| Flucytosine |
Increases antifungal activity in test tubes but also increases risk of bone marrow and kidney toxicity. |
| Foscarnet |
Should be used together with great caution. May decrease number of red blood cells and increases risk of kidney toxicity. |
| Ganciclovir |
Should be used together with great caution. May increase risk of bone marrow toxicity. |
| Gentamicin |
Should be used together with great caution. May increase risk of kidney toxicity. |
| Itraconazole |
May interfere with the activity of amphotericin B. |
| Kanamycin |
Should be used together with great caution. May increase risk of kidney toxicity. |
| Ketoconazole |
May interfere with the activity of amphotericin B. |
| Miconazole |
May interfere with the activity of amphotericin B. |
| Pentamidine (IV) |
Should be used together with great caution. May increase risk of kidney toxicity. |
| Tenofovir |
Should not be used together*. May increase risk of side effects. |
| Tobramycin |
Should be used together with great caution. May increase risk of kidney toxicity. |
| Amprenavir (Agenerase) plus ... |
| Abacavir |
Increases amprenavir level by 29% in blood. No dose adjustment recommended. |
| Alcohol |
Should not be used together. Alcohol and the oral formulation of amprenavir increases risk of side effects. |
| Alprazolam |
May increase alprazolam level in blood. |
| Amiodarone |
Should be used together with caution. May increase risk of side effects. Requires monitoring concentration of amiodarone. |
| Antacids |
Amprenavir should be taken 1 hour before or 1 hour after taking antacids. |
| Astemizole |
Should not be used together*. Increases risk of side effects. |
| Atazanavir |
Atazanavir may increase amprenavir levels in blood. |
| Atorvastatin |
Should be used together with great caution. May increase atorvastatin level in blood. |
| AZT |
Increases AZT level by 31% and increases amprenavir level by 13% in blood. No dose adjustment recommended. |
| Bepridil |
Should not be used together*. Increases risk of side effects. |
| Carbamazepine |
Should be used together with caution. May decrease amprenavir level in blood. |
| Cimetidine |
May increase amprenavir level in blood. |
| Cisapride |
Should not be used together*. Increases risk of side effects. |
| Clarithromycin |
Increases amprenavir level by 18% in blood. No dose adjustment recommended. |
| Clorazepate |
May increase clorazepate level in blood. |
| Clozapine |
May increase clozapine level in blood. |
| Dapsone |
May increase dapsone level in blood. |
| ddI or ddI EC |
Should be taken 1 hour before or after taking ddI tablets. ddI EC may be taken at the same time as amprenavir, but only on an empty stomach. |
| Delavirdine |
May increase amprenavir level in blood. No dose adjustment recommended. |
| Diazepam |
May increase diazepam level in blood. |
| Dihydroergotamine |
Should not be used together*. Increases risk of side effects. |
| Diltiazem |
May increase diltiazem level in blood. |
| Disulfiram |
Should not be used together with amprenavir oral solution*. Increases risk of side effects. |
| Efavirenz |
Decreases amprenavir level by 36% and increases efavirenz level by 15% in blood. Amprenavir dose may need to be increased. |
| Ergotamine |
Should not be used together*. Increases risk of side effects. |
| Erythromycin |
May increase erythromycin and amprenavir levels in blood. |
| Ethinyl estradiol |
Should not be used together. Amprenavir may decrease ethinyl estradiol and norethindrone levels in blood. Use another form of contraception. |
| Felodipine |
May increase felodipine level in blood. |
| Flurazepam |
May increase flurazepam level in blood. |
| Food (high fat) |
Decreases amprenavir level in blood and should be avoided. |
| Indinavir |
Increases amprenavir level by 33% and decreases indinavir level by 38% in blood. No dose adjustment recommended. |
| Itraconazole |
May increase itraconazole and amprenavir level in blood. Check for toxicity. |
| Kaletra |
Decreases lopinavir level by 15% and increases amprenavir trough level about 2-fold in blood. Amprenavir dose should be reduced to 750 mg twice a day or less. However, optimal dose is unclear. |
| Ketoconazole |
Increases amprenavir level by 31% and increases ketoconazole level by 44% in blood. Impact of interaction is uncertain. |
| Lidocaine (systemic) |
Should be used together with caution. Requires monitoring concentration of lidocaine. |
| Loratidine |
May increase loratidine level in blood. |
| Lovastatin |
Should be used together with great caution. May increase lovastatin level in blood. |
| Metronidazole |
Should not be used together with amprenavir oral solution*. Increases risk of side effects. |
| Midazolam |
Should not be used together*. Increases risk of side effects. |
| Nelfinavir |
Increases nelfinavir level by 15% in blood. No dose adjustment recommended. |
| Nevirapine |
May decrease amprenavir level in blood. Dose of amprenavir may need to be increased. |
| Norethindrone |
Should not be used together. Amprenavir may decrease ethinyl estradiol and norethindrone levels in blood. Use another form of contraception. |
| Nicardipine |
May increase nicardipine level in blood. |
| Nifedipine |
May increase nifedipine level in blood. |
| Nimodipine |
May increase nimodipine level in blood. |
| Phenobarbital |
Should be used together with caution. May decrease amprenavir level in blood. |
| Phenytoin |
Should be used together with caution. May decrease amprenavir level in blood. |
| Pimozide |
May increase pimozide level in blood. |
| Pravastatin |
Should be used together with great caution. May increase pravastatin level in blood. |
| Quinidine |
Should be used together with caution. Requires monitoring concentration of quinidine. |
| Rifabutin |
Decreases amprenavir level by 15% and increases rifabutin level by 193% in blood. A lower dose of rifabutin required. |
| Rifampin |
Should not be used together*. Significantly decreases amprenavir level in blood. |
| Ritonavir |
Increases amprenavir level by 70% in blood. Alternate dosing is amprenavir 600 mg + ritonavir 100 mg twice a day, or amprenavir 1,200 mg + ritonavir 200 mg once daily. |
| Saquinavir (Fortovase) |
Decreases amprenavir level by 32% and saquinavir level by 19% in blood. No dose adjustment likely required. |
| Sildenafil |
Should be used together with caution. May increase sildenafil level in blood. |
| Simvastatin |
Should be used together with great caution. May increase simvastatin level in blood. |
| St. John's Wort |
Should be used together with great caution. May significantly decrease amprenavir level in blood. |
| Tedalafil |
Should be used together with caution. May increase tedalafil level in blood. |
| Triazolam |
Should not be used together*. Increases risk of side effects. |
| Tricyclic antidepressants |
Should be used together with caution. Requires monitoring concentration of tricyclic antidepressants. |
| Vardenafil |
Should be used together with caution. May increase vardenafil level in blood. |
| Vitamin E |
Amprenavir capsules contain more than the recommended daily allowance for vitamin E. Additional supplementation, especially when used together with drugs like warfarin could result in hemorrhage. |
| Warfarin |
Should be used together with caution. Requires monitoring concentration of warfarin. |
| Atazanavir (Reyataz) plus... |
| Amiodarone |
Increases risk of side effects. Check amiodarone level and use with caution. |
| Amprenavir |
Atazanavir may increase amprenavir levels in blood. |
| Antacids |
May decrease atazanavir level in blood. Take atazanavir 2 hours before or 1 hour after taking antacids. |
| Atorvastatin |
Should be used together with great caution. May increase risk of side effects. |
| Bepridil |
Should not be used together*. Increases risk of side effects. |
| Calcium channel blockers |
Should be used together with great caution. Decrease dose of calcium channel blockers and check ECG. |
| Cisapride |
Should not be used together*. Increases risk of side effects. |
| Clarithromycin |
Increases risk of side effects and may decrease effectiveness of clarithromycin. Consider alternatives or reduce clarithromycin dose by at least 50%. |
| Cyclosporin |
Should be used together with caution. Check cyclosporine level. |
| ddI or ddI EC |
ddI buffered tablets can significantly decrease atazanavir level in blood. Take atazanavir (with food) either 2 hours before or 1 hour after buffered ddI tablets. Although ddI EC should not affect atazanavir level, they should be taken at least 1 hour apart. Atazanavir should be taken with food, and ddI EC should be taken on an empty stomach. |
| Diltiazem |
Should be used together with great caution. Decrease diltiazem dose by at least 50% and check ECG. |
| Ergot derivatives |
Should not be used together*. Increases risk of side effects. |
| Efavirenz |
Decreases atazanavir level in blood. Atazanavir should be boosted with ritonavir if used with efavirenz. |
| Ethinyl estradiol |
Should be used together with caution. Atazanavir increases ethinyl estradiol level in blood. Use lowest effective ethinyl estradiol dose. |
| Food |
High fat meal increases atazanavir by 35% and low fat meal increases atazanavir level by 70% in blood. Atazanavir should be taken with food. |
| Indinavir |
Should not be used together*. Increases risk of side effects. |
| Irinotecan |
Atazanavir may interfere with irinotecan metabolism. May increase irinotecan side effects. |
| Lidocaine (systemic) |
Increases risk of side effects. Check lidocaine level and use with caution. |
| Lovastatin |
Should not be used together*. Increases risk of side effects. |
| Midazolam |
Should not be used together*. Increases risk of side effects. |
| Norethindrone |
Should be used together with caution and decrease norethindrone dose to lowest effective dose. May increase norethindrone side effects, particularly in diabetic women. |
| Pimozide |
Should not be used together*. Increases risk of side effects. |
| Proton-pump inhibitors |
Should not be used together. May significantly decrease atazanavir level in blood. |
| Quinidine |
Increases risk of side effects. Check quinidine level and use with caution. |
| Rifabutin |
Increases rifabutin level. Decrease dose of rifabutin to 150 mg every other day or 3 times a week. |
| Rifampin |
Should not be used together. Decreases level of most protease inhibitors in blood. |
| Ritonavir |
Substantially increases atazanavir blood level. If combined, use atazanavir 300 mg (with food) + ritonavir 100 mg once daily. |
| Saquinavir (Fortovase) |
Increases saquinavir level by 5–6 fold in blood. Dose adjustments currently under study. |
| Sildenafil |
Increases sildenafil blood level. Decrease sildenafil dose to 25 mg every 48 hrs and check for side effects. |
| Simvastatin |
Should not be used together*. Increases risk of side effects. |
| Sirolimus |
Should be used together with caution. Check sirolimus level. |
| St. John's Wort |
Should not be used together. May reduce atazanavir level in blood. |
| Tacrolimus |
Should be used together with caution. Check tacrolimus level. |
| Tedalafil |
Should be used together with caution. May increase tedalafil level in blood. |
| Tenofovir |
Increases tenofovir level by 24% and decreases atazanavir level by up to 40% in blood. Atazanavir should be boosted with ritonavir if used with tenofovir. |
| Triazolam |
Should not be used together*. Increases risk of side effects. |
| Tricyclic antidepressants |
Increases risk of side effects. Check anti-depressant level and use with caution. |
| Vardenafil |
Should be used together with caution. May increase vardenafil level in blood. |
| Warfarin |
Should be used together with great caution. Has not been studied but may lead to serious side effects. |
| Azithromycin (Zithromax) plus ... |
| AZT |
May increase AZT level in blood. No dose adjustment recommended. |
| Cyclosporine |
May increase cyclosporine level in blood. |
| ddI or ddI EC |
May increase ddI level in blood. No dose adjustment recommended. |
| Digoxin |
May increase digoxin level in blood. |
| Ergot derivatives |
May increase ergot drug level in blood. |
| Food |
Azithromycin may be taken with or without food. |
| Hexobarbital |
May increase hexobarbital level in blood. |
| Midazolam |
May increase midazolam level in blood. No dose adjustment recommended. |
| Nelfinavir |
Should be used together with caution. Increases azithromycin level in blood. No dose adjustment recommended, but check for hearing and liver side effects. |
| Phenytoin |
May increase phenytoin level in blood. |
| Rifabutin |
May increase rifabutin level in blood. No dose adjustment recommended. |
| Theophylline |
May increase theophylline level in blood. No dose adjustment recommended. |
| Terfenadine |
May increase terfenadine level in blood. |
| Warfarin |
May increase warfarin level in blood. |
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