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Medical news

Smallpox Vaccine Safe in HIV-Infected Patients

From U.S. Centers for Disease Control and Prevention

October 28, 2008

Research presented Saturday at the 48th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy in Washington indicates that the third-generation smallpox vaccine IMVAMUNE is safe and effective for HIV-infected patients.

In the study, the vaccine was administered to HIV-positive and HIV-negative patients. No significant differences in safety or vaccine response were noted. The vaccine was well tolerated, though all patients reported mild to moderate injection site pain and redness.

"This is the first US trial systematically evaluating the safety and immunogenicity of a smallpox vaccine in HIV patients that has long-term data [six-month follow-up]," said lead investigator Dr. Richard N. Greenberg of the University of Kentucky School of Medicine.

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The finding has national security implications. "If smallpox is ever used as a weapon, IMVAMUNE will be an important vaccine for those who are immunocompromised or with atopic [allergic] skin reactions," Greenberg said.

Back to other news for October 2008

Reuters Health
10.27.2008; Anthony J. Brown, M.D.


  
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This article was provided by U.S. Centers for Disease Control and Prevention. It is a part of the publication CDC HIV/Hepatitis/STD/TB Prevention News Update. Visit the CDC's website to find out more about their activities, publications and services.
 
See Also
ICAAC/IDSA 2008 Newsroom



Please note: Knowledge about HIV changes rapidly. Note the date of this summary's publication, and before treating patients or employing any therapies described in these materials, verify all information independently. If you are a patient, please consult a doctor or other medical professional before acting on any of the information presented in this summary. For a complete listing of our most recent conference coverage, click here.

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