OraQuick Oral HIV Test Produces Higher Number of False Positives Than Expected, Study Finds
August 6, 2008
OraSure Technologies' OraQuick Advance Rapid HIV 1/2 Antibody Test produced more false positive results than expected when administered to patients in the emergency department at Brigham and Women's Hospital, according to a study published this week in the Annals of Internal Medicine, the Washington Post reports.
Instead of replacing the OraQuick test with a more accurate rapid test, the researchers learned to anticipate a higher number of false positives and act accordingly. Walensky said that although blood tests are more accurate, patients are less willing to receive a blood test than the OraQuick test, adding that "more people accept HIV testing" with the OraQuick test "than otherwise might."
Walensky said that physicians administering the OraQuick test should be prepared to handle potential false positives and discuss the possibility of a false positive with patients. Physicians also should ensure that all initial positive results are followed with a blood test.
According to the Post, 13% of EDs offered the OraQuick test in 2006, but that percentage likely has increased. Each hospital determines its own testing strategy, according to Bernhard Branson, a CDC epidemiologist and lead author of the 2006 guidelines that called for HIV testing in EDs. Christopher Pilcher, associate professor of medicine in the HIV/AIDS division at the University of California-San Francisco, said, "If we're going to ... start widely testing in a population where there hasn't been wide testing before, we're going to have to be really careful to have accurate and robust testing" (Ganguli, Washington Post, 8/5).
An abstract of the study is available online.
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This article was provided by Henry J. Kaiser Family Foundation. It is a part of the publication Kaiser Daily HIV/AIDS Report. Visit the Kaiser Family Foundation's website to find out more about their activities, publications and services.