Human Growth Hormone Could Reduce Fat Deposits Caused by HIV Treatment, JAMA Study Finds
August 4, 2008
Low doses of human growth hormone can reverse some of the abnormal fat distribution caused by HIV treatment and lower the risk of cardiovascular disease, but the hormone could increase the risk of side effects in people who have early stages of diabetes, according to a study published in the Journal of the American Medical Association and presented Sunday at the XVII International AIDS Conference, the Los Angeles Times reports.
Grinspoon said the hormone produced good results but would have to be used carefully to avoid inducing diabetes (Maugh, Los Angeles Times, 8/4). He also said use of the hormone is "not a panacea" (Tanner, AP/Google.com, 8/3). Grinspoon added that future trials should involve a diabetes drug, such as metformin, to reduce side effects (Los Angeles Times, 8/4). New antiretrovirals that produce fewer side effects also are needed, according to Grinspoon.
Jeffrey Lennox, an AIDS expert at Emory University, said that although there were fewer side effects with lower doses, the results of the study were "disappointing." Lennox said the results suggest hormone injections at best have limited use for treating fat abnormalities associated with HIV treatment (AP/Google.com, 8/3).
The study is available online.
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This article was provided by Henry J. Kaiser Family Foundation. It is a part of the publication Kaiser Daily HIV/AIDS Report. Visit the Kaiser Family Foundation's website to find out more about their activities, publications and services.