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An Overview of Selzentry (Maraviroc, Celsentri)

April 15, 2015

Selzentry 150Selzentry 300

Brand Name: Selzentry
Other Name(s): MVC
Drug Class: Entry and Fusion Inhibitors
Approved Use: Treatment of HIV Infection


Chemical Image

maraviroc chemical image

maraviroc
Molecular Weight: 513.6729



WARNING:

Maraviroc can cause serious, life-threatening side effects. These include liver problems, skin reactions, and allergic reactions. An allergic reaction may happen before liver problems occur.

Stop taking maraviroc and contact your health care provider right away if you have any of the following symptoms:

Stop taking maraviroc and contact your health care provider right away if you develop a rash with any of the following symptoms:

While taking maraviroc, it is important to keep all of your appointments with your health care provider.


What Is Maraviroc?

Maraviroc is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in adults. Maraviroc is always used in combination with other HIV medicines.

Maraviroc belongs to a class (group) of HIV drugs called entry inhibitors. Entry inhibitors block HIV from getting into and infecting certain cells of the immune system. This prevents HIV from multiplying and can reduce the amount of HIV in the body. Maraviroc works by attaching to one of two proteins on the surface of the immune cells. These proteins are called the CCR5 and CXCR4 coreceptors. Maraviroc attaches to the CCR5 coreceptor. When maraviroc attaches to the CCR5 coreceptor, certain strains of HIV -- called CCR5-tropic virus -- cannot attach to, enter, or infect the cell.

Maraviroc should be used only in people whose strain of HIV uses the CCR5 coreceptor. Maraviroc is not recommended for people whose HIV uses the CXCR4 coreceptor or both the CCR5 and CXCR4 coreceptors. Your health care provider will do a blood test to see whether your HIV uses only the CCR5 coreceptor.

HIV medicines can't cure HIV/AIDS, but taking a combination of HIV medicines (called an HIV treatment regimen) every day helps people with HIV live longer, healthier lives. HIV medicines also reduce the risk of HIV transmission.


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What Should I Tell My Health Care Provider Before Taking Maraviroc?

Before taking maraviroc, tell your health care provider:


How Should I Take Maraviroc?

Maraviroc comes in tablet form in two strengths, under the brand name Selzentry:

Take maraviroc according to your health care provider's instructions.

Take maraviroc with or without food. Swallow maraviroc tablets whole. Do not chew the tablets.

Always take maraviroc in combination with other HIV medicines.

If you take too much maraviroc, contact your health care provider or local poison control center (1-800-222-1222) right away, or go to the nearest hospital emergency room.

For more information on how to take maraviroc, see the FDA drug label from DailyMed. (DailyMed is a federal website that includes the most recent drug labels submitted to FDA.)


What Should I Do if I Forget a Dose?

If you miss a dose of maraviroc, take the missed dose as soon as you remember it and then take your next scheduled dose at its regular time. If it is less than 6 hours before your next dose, do not take the missed dose. Wait and take the next dose at the regular time. Do not take two doses at the same time to make up for a missed dose.


What Side Effects Can Maraviroc Cause?

Maraviroc can cause serious, life-threatening side effects. These include liver problems, skin reactions, and allergic reaction. An allergic reaction may happen before liver problems occur. (See the WARNING above.)

Other possible serious side effects of maraviroc include:

Tell your health care provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of maraviroc. To learn more about possible side effects of maraviroc, read the drug label or package insert or talk to your health care provider or pharmacist.

The AIDSinfo fact sheet on HIV Medicines and Side Effects also includes information that may apply to maraviroc.

You can also report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088) or online at www.accessdata.fda.gov/scripts/medwatch/.


How Should Maraviroc Be Stored?


Where Can I Find More Information About Maraviroc?

More information about maraviroc is available:


Manufacturer Information

ViiV Healthcare
877-844-8872

The above Patient Version drug summary is based on the following FDA label(s): Tablet (film coated).




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