| Disease |
Begin prophylaxis |
First Choice |
Alternative |
| Pneumocystis |
T-cell <200 or % <14 or oropharyngeal candidiasis (oral thrush) or unexplained fever >2 weeks |
TMP-SMX (Bactrim) 1 double strength (DS) everyday or 1 single strength (SS) everyday or 1 double strength three times a week |
Dapsone 50-100mg day or aerosolized pentamidine each month or Mepron (atrovoquone) 10 mL everyday (1500mg/day) |
| Toxoplasmosis gondi |
T-cell count <100 with a positive Toxoplasmosis IgG titer |
Bactrim, double strength tablet everyday -- Bactrim, 1 DS everyday |
Dapsone, 50-100 everyday plus pyrimethamine 50mg three times a week plus leucovorin 5mg three times a week |
| Mycobacterium Avium Complex |
T-cell <50 |
Azithromycin: 1200mg two pills once a week |
Clarithromycin: 500 mg twice daily; Rifabutin: 300 mg each day |
| Mycobacterium tuberculosis |
PPD reaction >5mm (skin testing) or history of a prior PPD result without treatment or contact with someone who has active disease |
Isoniazid 300mg + pyridoxine (vit B6) everyday for 12 months or Isoniazid 900mg + pyridoxine 50mg twice weekly for 12 months |
Rifampin 600mg everyday for 12 months |
| CMV Disease |
T-cell <50 with routine eye screening done every 3-6 months |
Oral Gancyclovir 1 gm three times a day (not routinely used as a primary prophylaxis because of poor absorption and the number of pills) |
None |
| Deep Fungal Infections, Cryptococcal neoformans or Histoplasmosis capsulum |
T-cell <100 |
Fluconazole 100mg everyday or 200mg three times a week (not widely recommended because of possible resist oral/esophagitis from Candidiasis |
None |
| Streptococcus pneumonia |
All patients regardless of T-cell count |
Pneumoncoccal vaccine, 0.5 mL once |
IV or IM IgG |
| Varicella virus |
Significant exposure to chicken pox or shingles for patients with no history of either condition or, if available, negative antibody titer |
Varicella zoster immune globulin (VZIG), 5 vials (1.25 mL each) IM, given <96 hours after exposure, ideally within 48 hours |
Acyclovir 800mg five times a day |
| Influenza A |
All patients (annually before influenza season, between September and November) |
Whole or split virus, 0.5 mL IM/year |
Rimantadine, 100mg two times daily or amandtadine, 100mg two times daily |
| Hepatitis B |
All susceptible (anti-HBc negative) patients |
Energix B, 20 ug IM on month 1, 2 and 6 |
Recombinvax HB, 10ug IM (intramuscular) |