July 17, 2008
HIV gradually depletes the number of functioning B cells, an antibody that fights infections, according to a recent study published in the Journal of Experimental Medicine that reveals another method used by HIV to affect the immune system, IANS/Thaindian News reports.
According to researchers from NIH's National Institute of Allergy and Infectious Diseases, B cells initially coat HIV particles to prevent them from infecting other cells, but the B cells tend to become exhausted and unable to fight off the infection. The study found that although HIV-positive people with high viral loads started with high levels of B cells, the cells failed to replicate normally or to produce high-quality antibodies needed to fight HIV. The researchers found that when B cells are overworked or fatigued, they tend to produce a protein called FCRL4, which inhibits the cells' ability to respond to infection (IANS/Thaindian News, 7/15). It is unknown how HIV triggers the production of FCRL4, the researchers noted (ANI/Thaindian News, 7/15).
According to an NIAID release, the institute's HIV vaccine research program aims to increase the understanding of B cells to help develop an effective vaccine. The researchers said that the design of a therapeutic vaccine aimed at slowing HIV progression will need to overcome or circumvent the challenges created by the failure of certain B cells to make high-quality antibodies (NIAID release, 7/14).
An abstract of the study is available online.
Reprinted with permission from kaisernetwork.org. You can view the entire Kaiser Daily HIV/AIDS Report, search the archives, or sign up for email delivery at www.kaisernetwork.org/dailyreports/hiv. The Kaiser Daily HIV/AIDS Report is published for kaisernetwork.org, a free service of the Kaiser Family Foundation, by The Advisory Board Company. © 2008 by The Advisory Board Company and Kaiser Family Foundation. All rights reserved.