SPV30 (also known as boxwood extract) is derived from the boxwood tree (Buxus sempervirens). In the mid nineties there was a lot of excitement about the use of SPV30 for HIV infection. Unfortunately, subsequent studies demonstrated very little benefit. Because highly active antiretroviral therapy has been shown to be much more effective in managing HIV infection, there is no longer much interest in this herb.

SPV30 is usually sold in capsules. It is not widely available. SPV30 has few known side effects, although some people in the American study did report occasional episodes of diarrhea or abdominal cramps.