Effect of Highly Active Antiretroviral Therapy on Incidence of Early Syphilis in HIV-Infected Patients
March 17, 2008
HIV-positive patients undergoing HAART (539) were followed for up to four years to identify early (primary or secondary) syphilis. After adjusting for calendar year, Poisson regression was used to evaluate incidence rate trends according to time from HAART initiation.
With median follow-up of 2.9 years, 56 (10.4 percent) patients experienced early syphilis -- 17 (3.2 percent) with primary syphilis, and 39 (7.2 percent) with secondary syphilis. Four years after HAART initiation, the overall incidence rate of early syphilis was 4.57 per 100 person-years (95 percent confidence interval, 3.45-5.93). The incidence rate of early syphilis significantly increased in proportion to the years after the initiation of HAART (3.4-6.1 per 100 person-year, P for trend "Early syphilis incidence in HIV-infected patients increased in proportion to HAART duration," the authors concluded. "This finding suggests that screening for syphilis in HIV-infected patients who initiate HAART should be encouraged with attention to the time passed since HAART initiation."
Sexually Transmitted Diseases
3.2008; Vol. 35; No. 3: P. 304-306; Wan Beom Park, MD, PhD; Hee-Chang Jang, MD; Sung-Han Kim, MD; Hong Bin Kim, MD, PhD; Nam Joong Kim, MD, PhD; Myoung-don Oh, MD, PhD; Kang Won Choe, MD, PhD
South Dakota Gov. Rounds Signs Bill That Requires People Convicted of Intentionally Spreading HIV to Register as Sex Offenders
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