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U.S. News

Drug-Resistant MRSA Strain Spreading Through MSM Communities in Boston, San Francisco, Researchers Say

January 15, 2008

A drug-resistant strain of methicillin-resistant staphylococcus aureus, or MRSA, is appearing among men who have sex with men in Boston and San Francisco, according to a study published online in the journal Annals of Internal Medicine, the New York Times reports (Altman, New York Times, 1/15). HIV-positive people "seem especially prone" to the infection, according to the San Francisco Chronicle (Russell, San Francisco Chronicle, 1/15).

For the study, Binh Diep, a researcher at the University of California San Francisco, and colleagues reviewed the charts of 183 people treated for MRSA at the San Francisco General Hospital's Positive Health Program, an outpatient program for HIV-positive people. They also reviewed the charts of an additional 130 people at Fenway Community Health clinic in Boston. The review found that MSM ages 18 to 35 were the most likely to have the infection (Chase, Wall Street Journal, 1/15). According to a statistical analysis based on ZIP codes, one in 588 people in San Francisco's Castro neighborhood, which has the highest number of MSM residents nationwide, is living with MRSA, compared with one in 3,800 people across San Francisco. The study also found that MSM in San Francisco were 13 times more likely than other city residents to contract MRSA (New York Times, 1/15).

The study found MRSA spreads most often through anal intercourse but also can be spread through casual skin-to-skin contact or by touching contaminated surfaces. MRSA can cause abscesses and skin ulcers and can produce necrotizing facsiitis, or flesh-eating bacteria. The infection also can cause pneumonia, heart damage and blood infections. Among MSM in the study, MRSA was spread through skin-to-skin contact and caused abscesses and infection in the buttocks and genitals. The most effective way to prevent skin-to-skin transmission of MRSA is to wash with soap and water, particularly after sex, the researchers said (New York Times, 1/15).

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According to the Chronicle, the strain, called USA300, is resistant to six major antibiotic classes (San Francisco Chronicle, 1/15). USA300 is resistant to two of the three alternative MRSA treatments recommended by CDC and the Infectious Diseases Society of America, the Times reports. The strain also is resistant to mupirocin, which has been "advocated for eradicating the strain from carriers," Henry Chambers, a study author and chief of infectious diseases at SFGH, said (New York Times, 1/15).

USA300 is "more virulent than standard staph," Shelly Gordon, an infectious disease specialist at California Pacific Medical Center, said. She added that emergency department physicians should test for drug resistance to avoid using the wrong antibiotic and fueling further resistance (Wall Street Journal, 1/15). Diep added that "once" the strain "reaches the general population, it will be truly unstoppable. That's why we're trying to spread the message of prevention."

According to the researchers, the increase in MRSA among MSM comes at a time when HIV, syphilis and rectal gonorrhea also are increasing in the population in part because of an increase in risky sexual behavior and injection drug use. The "likelihood of contracting each of these diseases increases with the number of sexual partners that you have," Diep said, adding that the "same can probably be said for MRSA" (Beck, Reuters, 1/14). Chambers said that high antibiotic use is the "most important factor" that the new drug-resistant strain is appearing among MSM (Wall Street Journal, 1/15).

According to Francoise Perdreau-Remington -- director of the molecular epidemiology lab at SFGH, where the strain was first identified -- USA300 has been found in 44 states and is beginning to spread through Europe. In 2007, CDC calculated that about 19,000 U.S. residents -- more than the number of people who die annually from AIDS-related causes -- died from drug-resistant strains of MRSA (San Francisco Chronicle, 1/15).

Online The study is available online.

NPR's "All Things Considered" on Monday reported on the study. The segment includes comments from Steve Boswell, president and CEO of the Fenway Community Health Center, and Diep (Knox, "All Things Considered," NPR, 1/14). Audio and a partial transcript of the segment, as well as expanded NPR coverage, are available online.

Back to other news for January 2008


Reprinted with permission from kaisernetwork.org. You can view the entire Kaiser Daily HIV/AIDS Report, search the archives, or sign up for email delivery at www.kaisernetwork.org/dailyreports/hiv. The Kaiser Daily HIV/AIDS Report is published for kaisernetwork.org, a free service of the Kaiser Family Foundation, by The Advisory Board Company. © 2007 by The Advisory Board Company and Kaiser Family Foundation. All rights reserved.



  
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This article was provided by Henry J. Kaiser Family Foundation. It is a part of the publication Kaiser Daily HIV/AIDS Report. Visit the Kaiser Family Foundation's website to find out more about their activities, publications and services.
 
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