Antimicrobial Susceptibility of Neisseria Gonorrheae Strains in Three Regions of Armenia
September 13, 2007
There is a lack of available data on gonococcal susceptibility in the Caucasus region, the authors of the current study noted. They aimed to determine in vitro antimicrobial susceptibility of Neisseria gonorrheae in Armenia in order to update the national treatment protocol.
Isolates from men with urethral discharge who presented at three STD clinics in three different locations were used to determine susceptibility of N. gonorrheae strains for 11 antimicrobials via disc diffusion technique.
Among the 101 isolates tested, the respective susceptibility rates for penicillin, doxycycline, and kanamycin were 37.6, 25.7, and 80.2 percent. For both ofloxacin and ciprofloxacin, sensitivity to quinolones was 95 percent. All strains were susceptible to third-generation cephalosporines and to spectinomycin. Just 11 percent of strains were susceptible to all antibiotics tested.
"Third-generation cephalosporines and spectinomycin are suitable first-line regimens," the authors concluded. "Quinolones are not advisable as first-line treatment given current borderline susceptibility, known tendency for rapid resistance development in this class, and frequent over-the-counter use of this antibiotic in Armenia."
Sexually Transmitted Diseases
09.2007; Vol. 34; No. 9: P. 686-688; Gayane Hovhannisyan, M.D.; Tido von Schoen-Angerer, M.D.; Karen Babayan, M.D., Ph.D.; Olivier Fenichiu, M.D.; Valeria Gaboulaud, M.D.
This article was provided by CDC National Prevention Information Network. It is a part of the publication CDC HIV/Hepatitis/STD/TB Prevention News Update.