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An Overview of Crixivan (Indinavir)

February 23, 2017

Brand Name: Crixivan
Other Name(s): IDV, indinavir sulfate
Drug Class: Protease Inhibitors



Indinavir can cause serious, life-threatening side effects. These include kidney problems, hemolytic anemia (a rapid breakdown of healthy red blood cells), and liver problems.

Contact your health care provider right away if you have any of the following symptoms that could be signs of kidney problems:

  • Pain in your middle to lower stomach or back area (kidney pain)
  • Blood in your urine

Contact your health care provider right away if you have any of the following symptoms that could be signs of hemolytic anemia:

  • Feeling weak or tired
  • Yellowing of your skin or the whites of your eyes (jaundice)
  • Pale skin color
  • Feeling dizzy
  • Fast heartbeat

Contact your health care provider right away if you have any of the following symptoms that could be signs of liver problems:

  • Yellowing of your skin or the whites of your eyes (jaundice)
  • Dark-colored urine
  • Light-colored bowel movements
  • Loss of appetite for several days or longer
  • Nausea
  • Pain in the stomach area (abdominal pain)

While taking indinavir, it is important to keep all of your appointments with your health care provider.

What Is Indinavir?

Indinavir is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in adults. Indinavir is always used in combination with other HIV medicines.

Indinavir belongs to a class (group) of HIV drugs called protease inhibitors (PIs). PIs block an HIV enzyme called protease. (An enzyme is a protein that starts or increases the speed of a chemical reaction.) By blocking protease, PIs prevent HIV from multiplying and can reduce the amount of HIV in the body.

HIV medicines can't cure HIV/AIDS, but taking a combination of HIV medicines (called an HIV regimen) every day helps people with HIV live longer, healthier lives. HIV medicines also reduce the risk of HIV transmission. If you are taking HIV medicines, including indinavir, don't cut down on, skip, or stop taking them unless your health care provider tells you to.


What Should I Tell My Health Care Provider Before Taking Indinavir?

Before taking indinavir, tell your health care provider:

  • If you are allergic to indinavir or any other medicines.
  • If you have or have ever had liver problems, especially mild or moderate liver disease caused by cirrhosis (scarring of the liver).
  • If you have kidney problems.
  • If you have diabetes.
  • If you have hemophilia.
  • If you have high cholesterol and are taking cholesterol-lowering medicines called statins.
  • If you have any other medical conditions
  • If you are pregnant or plan to become pregnant. Whether indinavir can harm an unborn baby is unknown. Indinavir should be used during pregnancy only if the potential benefits outweigh the risks. Talk to your health care provider about possible risks with taking indinavir when pregnant.
  • If you are breastfeeding or plan to breastfeed. Do not breastfeed if you are infected with HIV or are taking indinavir.
  • If you are using hormone-based birth control (such as pills, implants, or vaginal rings). For more information about using birth control and HIV medicines at the same time, view the AIDSinfo HIV and Birth Control infographic.
  • About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Indinavir may affect the way other medicines or products work, and other medicines or products may affect how indinavir works. Taking indinavir together with certain medicines or products may cause serious, life-threatening side effects.

How Should I Take Indinavir?

Indinavir (brand name: Crixivan) comes in capsule form in two different strengths:

  • 200-mg capsules
  • 400-mg capsules

Take indinavir according to your health care provider's instructions.

Take indinavir capsules every 8 hours around the clock, every day.

Typically, indinavir is taken with water or another beverage on an empty stomach (e.g., 1 hour before a meal or 2 hours after a meal). Your health care provider may allow you to take indinavir with a snack or small meal that is low in calories, fat, and protein. Follow the instructions your health care provider gives you. Drink at least 6 8-ounce beverages (preferably water) throughout the day to reduce the risk of kidney stones. Eight ounces equals 1 cup.

Always take indinavir in combination with other HIV medicines.

If you take too much indinavir, contact your health care provider or local poison control center (1-800-222-1222) right away, or go to the nearest hospital emergency room.

For more information on how to take indinavir, see the FDA drug label from DailyMed. (DailyMed is a federal website that includes the most recent drug labels submitted to FDA.)

What Should I Do If I Forget a Dose?

If you miss a dose of indinavir by more than 2 hours, wait and then take the next dose at the regularly scheduled time. If you miss a dose by less than 2 hours, take the missed dose immediately. Then take your next dose at the regularly scheduled time. Do not take more or less than your prescribed dose of indinavir at any one time.

What Side Effects Can Indinavir Cause?

Indinavir may cause side effects. Most side effects from indinavir are manageable, but a few can be serious. Serious side effects of indinavir include kidney problems, hemolytic anemia (rapid breakdown of healthy red blood cells), and possibly liver problems. (See the WARNING above.)

Other possible side effects of indinavir include:

  • Diabetes and high blood sugar (hyperglycemia).
  • Changes in body fat (including gain or loss of fat).
  • Changes in your sense of taste.
  • Severe muscle pain and weakness in people also taking cholesterol-lowering medicines called statins.
  • Increased bleeding in people with hemophilia.
  • Immune reconstitution inflammatory syndrome (IRIS), a condition that sometimes occurs when the immune system begins to recover after treatment with an HIV medicine. As the immune system gets stronger, it may have an increased response to a previously hidden infection.

Tell your health care provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of indinavir. To learn more about possible side effects of indinavir, read the drug label or package insert or talk to your health care provider or pharmacist.

The AIDSinfo fact sheet on HIV Medicines and Side Effects also includes information that may apply to indinavir.

You can also report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088) or online at

How Should Indinavir Be Stored?

  • Store indinavir at room temperature, 59°F to 86°F (15°C to 30°C).
  • Keep indinavir in the container that it came in and keep the container tightly closed. If the container has a small packet of drying agent (called a desiccant), do not remove it. The desiccant protects the medicine from moisture.
  • Do not use indinavir if the original seal over the container opening is broken or missing.
  • Throw away indinavir that is no longer needed or expired (out of date). Follow FDA guidelines on how to safely dispose of unused medicine.
  • Keep indinavir and all medicines out of reach of children.

Where Can I Find More Information About Indinavir?

More information about indinavir is available:

Manufacturer Information

Merck & Co., Inc.
Main number: 908-423-1000
Patient assistance: 800-727-5400

The above Patient Version drug summary is based on the following FDA label(s): Capsule.

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This article was provided by AIDSinfo. Visit the AIDSinfo website to find out more about their activities and publications.